Experience With Hypothermic Machine Perfusion in Expanded Criteria Donors: Functional Outcomes

Hernández, Mercedes Ruíz; Santos, Victoria Gómez-Dos; Díaz-Pérez, D.E.; Fernández-Alcalde, Á.; Hevia, Vital; Álvarez-Rodríguez, Sara; Diez-Nicolás, V.; Elías-Triviño, S.; Burgos-Revilla, F.J.

doi:10.1016/j.transproceed.2018.09.020

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…In extend criteria donor (ECD) kidneys, use of HMP enhances 1-year graft survival [41]. However, HMP has not shown a convincing benefit in prolonging longer-term graft survival [42].…”

Section: Hypothermic Machine Perfusionmentioning

confidence: 99%

Advances in Hypothermic and Normothermic Perfusion in Kidney Transplantation

2021

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Hypothermic and normothermic machine perfusion in kidney transplantation are purported to exert a beneficial effect on post-transplant outcomes compared to the traditionally used method of static cold storage. Kidney perfusion techniques provide a window for organ reconditioning and quality assessment. However, how best to deliver these preservation methods or improve organ quality has not yet been conclusively defined. This review summarises the promising advances in machine perfusion science in recent years, which have the potential to further improve early graft function and prolong graft survival.

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“…In extend criteria donor (ECD) kidneys, use of HMP enhances 1-year graft survival [41]. However, HMP has not shown a convincing benefit in prolonging longer-term graft survival [42].…”

Section: Hypothermic Machine Perfusionmentioning

confidence: 99%

Advances in Hypothermic and Normothermic Perfusion in Kidney Transplantation

2021

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“…None of the donors had history of hepatitis B infection. The median donor age was 21 (19)(20)(21)(22)(23)(24)(25)(26) years. Three grafts were from DCD donors and 1 was from a DBD donor.…”

Section: Donor Characteristicsmentioning

confidence: 99%

“…The median operation duration was 370 (350-405) min, and the median anhepatic phase was 34 (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38) min. The median ICU stay was 48 (23-85) h, and the median length of hospital stay was 26 (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) days. In addition, recipient 1 in the study experienced postreperfusion syndrome (PRS), which was diagnosed by a decrease of 33% in mean arterial pressure (MAP) after anhepatic phase for 5 min with the use of norepinephrine (0.2 ug/kg/min) within the first 5 min after reperfusion.…”

Section: Post-transplant Outcomes and Liver Graft Functionmentioning

confidence: 99%

“…It is difficult for surgeons to decide whether to use an ECD liver for transplantation or to discard it due to an expected high risk of PNF, based on surgeon experience [23]. Fortunately, advances have been made in machine perfusion (MP) technology, including hypothermic machine perfusion (HMP), hypothermic oxygenated perfusion (HOPE), subnormothermic machine perfusion (SNMP), and NMP [11,[24][25][26]. HMP of kidneys can reduce the incidence of delayed graft function (DGF) in renal transplantation [27].…”

Section: Case Reportmentioning

confidence: 99%

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First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia

Zhang

Tang

et al. 2020

Ann Transplant

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Background: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. Case Reports: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. Conclusions: NMP provides a potential tool for preservation and assessment of ECD livers in China.

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