Experience with polyethylene glycol allergy‐guided risk management for COVID‐19 vaccine anaphylaxis

Abstract

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Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID‐19 vaccines?

“…In another case, PEG 1500 and PEG 6000 were used at concentrations from 5 ng/ml to 500.000 ng/ml and PEG 4000 at concentrations ranging from 1.5 ng/ml to 500 mg/ml. 26 Polysorbate 80 was positive at 0.02 mg/ml in one case. 24 …”

“…In most studies, BNT‐vaccine was used in the BAT at four concentrations ranging from 0.05 µg/ml to 10 µg/ml, 27 0.01 µg/ml to 10 µg/ml 28 or 0.18 µg/ml to 22.7 µg/ml. 26 In two studies, only one concentration for mRNA vaccines was used (0.007 µg/µl and 1 µl, respectively). 8 , 9 Best positive results were found for concentrations around 10 µg/ml.…”

“…M‐vaccine was used in only two studies with a concentration of 0.007 µg/µl 8 or a range from 0.36 µg/ml to 45.45 µg/ml. 26 In BHRT, M‐vaccine was used at six concentrations. 29 …”

“…AZ‐vaccine was used in a series of dilutions ranging from 1:2000 to 1:10 27 or from undiluted to 1:125 (division by 4.4 to calculate the final concentration). 26 In BHRT, AZ‐vaccine was used at six concentrations. 29 …”

“…DMG‐PEG 2000 as a component of the M‐vaccine was used in the BAT at one concentration (1 µg/µl) 8 or at three concentrations (0.0728 µg/ml to 1.82 µg/ml), 26 and in the BHRT at six concentrations. 29 …”