Experience with MAD on children with epilepsy in Egypt after classic KD failure

Abstract

After nine months of MAD, growth and seizure parameters significantly improved in the intractable epilepsy patients as well as their mothers& QoL. We thus recommend MAD as a more flexible alternative in intractable epilepsy patients who can not tolerate classic KD.

Seizure severity is associated with poor quality of life in people living with epilepsy (PLWE) in Uganda: A cross-sectional study

“…For this study, the analyses of seizure severity, the outcome was the total CSSS score (we selected the total CSSS score rather than the CSSS score for the specific seizure type because of the stipulation above regarding potential misclassification of seizure types reported by caregivers or patients). The Chalfont seizure severity score has been used in one epilepsy study in similar settings (16). It provides features of both a patient-based and an observer-based scale obtained by open interview of patients and caregivers with factor weightings were affected by the views of patients, caregivers and health care providers.…”

Qualitative exploration of feasibility and acceptability of the modified Atkins diet therapy for children with drug resistant epilepsy in Kenya

“…The possibility for reduction or cessation of anti-seizure medication use was a major motivating factor as caregivers perceived MADT to be a safer option compared to medications, despite complications of MADT that were experienced, including weight loss, weight gain, and constipation. Satisfaction with Atkins diets has been found to vary according to food preferences of children, culture, and facilitation [22,24,42]. In this study, satisfaction with the MADT was closely related to how effective the intervention was in reduction of seizures.…”

“…Enabling factors which should be harnessed in future implementation of MADT include; enlisting extended family support and establishment of support groups that include families whose children are on dietary therapies for the management of epilepsy. Parent support groups as key factors in determining the success of MADT implementation have been cited in studies by El Rashidy and Park [22,40].…”

“…Utilization of dietary therapies, including MADT, has been proposed as an intervention to aid in the closure of the epilepsy treatment gap [9,10,19]. Acceptability of MADT in various settings has been linked to healthcare worker support to mitigate against factors such as illiteracy and distance, flexibility in allowing slower reduction of the carbohydrate portions, use of patient support groups, and utilization of available local foods in the implementation of MADT [20][21][22][23][24]. There are minimal data available on utilization of dietary therapies for children with drug-resistant epilepsy in Sub-Saharan Africa.…”

The efficacy of non-fasting ketogenic diet protocol in the management of intractable epilepsy in pediatric patients: a single center study from Saudi Arabia

“…The efficacy results shown in the present study were similar to that of other published studies. 24 – 26 …”