Experience with split-course external beam irradiation ± chemotherapy and integrated Ir-192 high-dose-rate brachytherapy in the treatment of primary carcinomas of the anal canal

Kapp, Karin S.; Geyer, E.; Gebhart, Florian; Oechs, Astrid; Berger, Anton; Hebenstreit, J.; Stoeger, Herbert

doi:10.1016/s0360-3016(00)01427-9

Cited by 30 publications

(20 citation statements)

References 39 publications

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“…The reported incidence of ulceration as a late complication was between 1.2-22.6%, and 2.3-7.6% of chronic ulcer needed a surgical intervention [3,[64][65][66][67][68][69][70]. Two early small cases studies reported that ulcers led to formation of anal stricture (1 out of 30 and 1 out of 12, respectively) [71,72].…”

Section: Ulcerationmentioning

confidence: 99%

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

et al. 2018

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Introduction: There is a paucity of data on incidence and mechanisms of long-term gastrointestinal consequences after chemoradiotherapy for anal cancer. Most of the adverse effects reported were based on traditional external beam radiotherapy whilst only short-term follow-ups have been available for intensity-modulated radiotherapy, and there is lack of knowledge about consequences of doseescalation radiotherapy. Method: A systematic literature review. Results: Two thousand nine hundred and eighty-five titles (excluding duplicates) were identified through the search; 130 articles were included in this review. The overall incidence of late gastrointestinal toxicity was reported to be 7-64.5%, with Grade 3 and above (classified as severe) up to 33.3%. The most commonly reported late toxicities were fecal incontinence (up to 44%), diarrhea (up to 26.7%), and ulceration (up to 22.6%). Diarrhea, fecal incontinence and buttock pain were associated with lower scores in radiotherapy specific quality of life scales (QLQ-CR29, QLQ-C30, and QLQ-CR38) compared to healthy controls. Intensity-modulated radiation therapy appears to reduce late toxicity. Conclusion: Late gastrointestinal toxicities are common with severe toxicity seen in one-third of the patients. These symptoms significantly impact on patients' quality of life. Prospective studies with control groups are needed to elucidate long-term toxicity.

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Section: Ulcerationmentioning

confidence: 99%

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

et al. 2018

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“…Another way to intensify treatment is limitation of treatment breaks duration: feasibility has been studied in some phase II studies, with different schedules [19,20,35,[40][41][42]. Phase III studies could objectively evaluate impact of treatment break reduction on local control, colostomy-free and overall survival.…”

Section: Discussionmentioning

confidence: 99%

Is neoadjuvant chemotherapy prior to radio‐chemotherapy beneficial in T4 anal carcinoma?

Moureau-Zabotto

Viret

Giovaninni

et al. 2011

Journal of Surgical Oncology

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“…Interstitial brachytherapy is the standard treatment in patients with anal cancer where sphinctersaving surgery is not possible (1,4,11,17,18). Obtaining better image guidance for dose planning could allow a reduction in the implant volume in some patients, thereby decreasing the likelihood of late sequelae, and may also influence the risk of local recurrence.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional endoluminal ultrasound-guided interstitial brachytherapy in patients with anal cancer

2008

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Experience with split-course external beam irradiation ± chemotherapy and integrated Ir-192 high-dose-rate brachytherapy in the treatment of primary carcinomas of the anal canal

Cited by 30 publications

References 39 publications

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review

Is neoadjuvant chemotherapy prior to radio‐chemotherapy beneficial in T4 anal carcinoma?

Three-dimensional endoluminal ultrasound-guided interstitial brachytherapy in patients with anal cancer

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