Electronic nicotine delivery systems (ENDS, commonly referred to as e‐cigarettes), have become popular among young adults (YAs, 18–24 years) in the United States. YAs in rural areas increasingly consume more ENDS than those in urban areas. However, there is a knowledge gap regarding the perspectives of public health advocates (PHAs) on ENDS use and cessation among YAs in rural areas.The objectives of the study are to describe the perspectives of PHAs and identify strategies to strengthen the capacity for promoting the cessation of ENDS among YAs in rural communities.A qualitative study and interpretive description were used with semi‐structured interviews. The content analysis was used to analyze the data.Twenty‐two PHAs, including public health officers, nurses, and tobacco‐free educators, from Wisconsin, Minnesota, and North Dakota, were invited to the semi‐structured interviews.Four themes emerged: (a) Perceived ENDS use and cessation; (b) rural contexts and infrastructure influencing ENDS use; (c) essential public health responsibilities controlling ENDS use in rural areas; and (d) regulating ENDS use: Policies and law. PHAs stressed the importance of increased awareness of ENDS use in YAs, improved regulation, and tailored policies to tackle rural communities’ distinct challenges.The study emphasizes the urgency for specialized programs to aid YAs in quitting ENDS in rural areas. A comprehensive strategy is needed to effectively address ENDS use among YAs in rural areas, involving education, policy adjustments, and community‐based initiatives.