Experiences from vaccination and revaccination of teenage girls with three different rubella vaccines

Böttiger, M; Heller, L.

doi:10.1016/0092-1157(76)90020-2

Cited by 29 publications

(4 citation statements)

References 1 publication

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“…rhinitis, cough, conjunctivitis, and sore throat) were registered in 14n0 % of vaccine recipients ; a mild fever ( 38 mC) was observed in 7n0 % of subjects (Table 2). These signs and symptoms were transitory, and none required special treatment, as has been reported following other investigations with the RA27\3-strain rubella virus vaccines among preadolescent girls [25,26] or adult men and women [27]. Overall, vaccine-associated reactions and natural rubella infection-related reactions appeared to occur with the same frequency.…”

Section: Rubella Vaccine Immunization (1996)supporting

confidence: 72%

Rubella in the Russian Federation: epidemiological features and control measures to prevent the congenital rubella syndrome

et al. 2000

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A review of the epidemiology of clinical rubella in the Perm region of the Russian Federation from 1979-97 showed that the incidence was about 220 cases per 100,000 population. Congenital rubella syndrome (CRS) accounted for 15% of birth defects and for about 3.5 cases of CRS per 1000 live births per year. Surveys of the seroepidemiology of rubella infection revealed that the susceptibility rate among pregnant women (i.e. rubella virus antibody haemagglutination-inhibition (HAI) assay titres < 10) was 16.5%. As serum rubella antibody HAI titres > or = 10 both prevented infection in pregnant women and protected their foetuses, serological testing has been introduced into the routine antenatal services. Pre-existing rubella antibodies were found not to interfere with the immune response to vaccination, so selective immunization was provided to girls approaching puberty and to women of childbearing age. A programme of epidemiological surveillance is being developed to define tactics for the widescale introduction of rubella vaccination.

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Section: Rubella Vaccine Immunization (1996)supporting

confidence: 72%

Rubella in the Russian Federation: epidemiological features and control measures to prevent the congenital rubella syndrome

et al. 2000

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“…It is administered in a 2-dose series as a component of the measles-mumpsrubella (MMR II) vaccine. Seroprotective levels are as high as 98% after the second dose [7,8]. Protective levels of humoral immunity are observed 20 years after vaccination [9].…”

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confidence: 99%

Polymorphisms in HLA-DPB1 Are Associated With Differences in Rubella Virus-Specific Humoral Immunity After Vaccination

Lambert¹,

Haralambieva²,

Kennedy³

et al. 2014

Journal of Infectious Diseases

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Vaccination with live attenuated rubella virus induces a strong immune response in most individuals. However, small numbers of subjects never reach or maintain protective antibody levels, and there is a high degree of variability in immune response. We have previously described genetic polymorphisms in HLA and other candidate genes that are associated with interindividual differences in humoral immunity to rubella virus. To expand our previous work, we performed a genome-wide association study (GWAS) to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific neutralizing antibodies. We identified rs2064479 in the HLA-DPB1 genetic region as being significantly associated with humoral immune response variations after rubella vaccination (P = 8.62 × 10(-8)). All other significant SNPs in this GWAS were located near the HLA-DPB1 gene (P ≤ 1 × 10(-7)). These findings demonstrate that polymorphisms in HLA-DPB1 are strongly associated with interindividual differences in neutralizing antibody levels to rubella vaccination and represent a validation of our previous HLA work.

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“…Some of these have been found to be commoner after RA27/3 and are particularly disturbing for women who are vaccinated post partum (Best, Banatvala & Bowen, 1974;Sharp & MacDonald, 1973). In schoolgirls the choice should depend solely upon the immunogenic properties of the vaccine, because side-effects at this age are mild and infrequent (Zealley, 1974;Freestone, Reynolds, McKinnon & Prydie, 1975;Bottiger & Heller, 1976). If reinfection is a risk to the fetus, then RA27/3 appears to be preferable.…”

Section: Discussionmentioning

confidence: 99%

Antibody titres in women six to eight years after the administration of RA27/3 and Cendehill rubella vaccines

MacDonald

et al. 1978

J. Hyg.

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SummaryTitres of haemagglutination-inhibiting antibody have been measured repeatedly in young women during a period of 6–8 years after the administration of RA27/3 and Cendehill attenuated rubella vaccines. Mean antibody titres were initially 217 after RA27/3 and 159 after Cendehill, but the difference diminished after the first year. Antibody titres were subsequently well maintained in both groups and did not reveal any need for regular revaccination. Mean titres in the Cendehill group were partly maintained by symptomless reinfection which was commoner after Cendehill than after RA27/3. Significant falls in titre were equally common after both vaccines, but low titres of 30 or less were more frequent in subjects who had received Cendehill.Mean neutralizing antibody titres were initially 15·4 after RA27/3 vaccine and 9 after Cendehill. Titres remained higher after RA27/3 for 3 years, but the difference then diminished and became insignificant during the fifth year.Revaccination of women with low antibody titres produced significant increases in 69% of subjects when standard RA27/3 vaccine was used; a special preparation of RA27/3 of higher potency produced a similar number of rises (70%) but elicited higher titres and might occasionally be useful for revaccinating women who are likely to come into contact with rubella. Challenge with RA27/3 vaccine produced weaker responses in women who had experienced natural infection than in those whose antibody was vaccine-induced.Rises in antibody titre after revaccination consisted mainly of IgG, but traces of IgM antibody were detected in one vaccinee who had recently experienced natural reinfection and in 1 woman with naturally acquired antibody who had been challenged with high titre RA27/3 vaccine.

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Experiences from vaccination and revaccination of teenage girls with three different rubella vaccines

Cited by 29 publications

References 1 publication

Rubella in the Russian Federation: epidemiological features and control measures to prevent the congenital rubella syndrome

Rubella in the Russian Federation: epidemiological features and control measures to prevent the congenital rubella syndrome

Polymorphisms in HLA-DPB1 Are Associated With Differences in Rubella Virus-Specific Humoral Immunity After Vaccination

Antibody titres in women six to eight years after the administration of RA27/3 and Cendehill rubella vaccines

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