Experiences in Hepatic Surgery and Transplantation after Radioembolization

Abstract

Yttrium-90 microspheres radioembolization has shown to be an effective modality of treatment in patients with primary or metastatic liver tumours [1-4]. It is usually offered to patients with advanced liver cancers. However, surgical experience after radioembolization is very limited to anecdotal cases mainly related to hepatocellular carcinoma. We have treated patients with hepatocellular carcinoma or liver metastasis mainly from colon, breast, melanoma and neuroendocrine tumours. In our experience after such treatment we were able to downstage the tumour to surgery only in the case of hepatocellular carcinoma. Five patients had liver transplantation and 1 had right hepatic resection after Yttrium-90 microspheres radioembolization. Of note 2 patients had neoplastic infiltration of a portal vein branch which resolved after treatment with Yttrium-90 microspheres radioembolization. The extra-hepatic spread was ruled out and later they were both transplanted. Here we report our initial single center experience with Yttrium-90 microspheres radioembolization as downstaging and bridging method for hepatocellular carcinoma prior liver surgery, resection or liver transplantation.

Transarterial radioembolization for liver tumors as neoadjuvant therapy: three case reports

“…They obtained a conversion for liver transplantation by 11%, in which we treated with TARE, initially as a palliative modality only. (7) In systematic review, Braat et al, presented studies that showed evidences of benefits of neodjuvant use of TARE in intra-hepatic colangiocarcinoma, in addition to hepatocarcinoma. (9) There were no cases of progression of the disease during time of waiting for surgical intervention.…”

“…(1,4,5) The neoadjuvant objective of this treatment is still controversy, but selected cases of injures initially considered unresectable, when undergoing TARE, are reclassified as candidates to the curative therapy. (4,6,7) ❚ OBJECTIVE To report 3 cases of liver tumors in which transarterial radioembolization of the liver was used as a neoadjuvant therapy.…”

Assessment & Effectiveness of Surgeries in Human Safety

“…related to the person receiving the organ transplant [56,57], such as a parent, sibling, or child, living unrelated donor such as a friend or spouse, deceased donor is a person who has recently died and who has no known chronic kidney disease. In these kinds of surgeries [58] the surgeon places the new kidney inside your lower belly. The artery and vein of the new kidney are connected to the artery and vein in your pelvis.…”

A Confront on Cancer allied Diabetic Patients

“…Standard diagnosis for bladder cancer is biopsy which is obtained during cystoscopy [89]. In some cancer cases patients are generally treated by removing only part of the bladder, and that procedure is followed by radiation, chemotherapy and immunological therapy [90][91][92]. Surgical therapy includes Trans Urethral Resection of Bladder Tumor (TURBT), partial or complete Cystectomy.…”