Experiences in the molecular genetic and histopathological evaluation of calpainopathies

Özyılmaz, Berk; Kırbıyık, Özgür; Özdemir, Taha Reşi̇d; Özer, Özge; Kutbay, Yaşar Bekir; Erdoğan, Kadri Murat; Güvenç, Merve Saka; Arıkan, Şener; Turk, Tuba Sozen; Kale, Murat Yıldırım; Uludağ, İrem Fatma; Baydan, Figen; Sertpoyraz, Filiz Meryem; Gençpınar, Pınar; Diniz, Gülden

doi:10.1007/s10048-022-00687-4

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2022

2023

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Cited by 4 publications

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confidence: 99%

New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain

2022

Journal of Cellular Signaling

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in various neurodegenerative [3], neuromuscular [4], and cardiac disorders [5,6]. The development and testing of Calpain inhibitors as therapeutic agents is the subject of intense ongoing research [3,5,7]. One emerging target of Calpain cleavage under pathophysiological conditions is Junctophilin-2 (JP2) [8,9]. Recently, we systematically analyzed the JP2 cleavage products as a function of Calpain-1 versus Calpain-2 proteolytic activities [10]. Together with newly

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confidence: 99%