Experiences with fetomaternal alloimmune thrombocytopenia in the Netherlands over a 2-year period

Serrarens-Janssen, V.M.L.; Steegers, Eric A.P.; Bos, A. Van Den; Heijst, Arno van; Pereira, Rodrigues; Semmekrot, B.A.

doi:10.1111/j.0001-6349.2005.00653.x

Cited by 3 publications

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“…Fetomaternal alloimmune thrombocytopenia (FMAIT) is the most common cause of severe neonatal thrombocytopenia in otherwise well, term infants (Dreyfus et al , 1997). The condition results from a fetomaternal incompatibility in human platelet alloantigens (HPAs), most commonly HPA‐1a, and can lead to serious bleeding, intracranial haemorrhage (ICH) and sometimes death of the fetus or infant (Serrarens‐Janssen et al , 2005). The fetal and neonatal thrombocytopenia caused by anti‐platelet antibodies is analogous to the fetal and neonatal anaemia caused by anti‐red cell antibodies in haemolytic disease of the fetus and newborn (HDFN).…”

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“…The fetal and neonatal thrombocytopenia caused by anti‐platelet antibodies is analogous to the fetal and neonatal anaemia caused by anti‐red cell antibodies in haemolytic disease of the fetus and newborn (HDFN). The incidence of clinically affected infants is estimated to be 1 in 15 000 births in European populations (Williamson et al , 1998; Serrarens‐Janssen et al , 2005). In contrast to HDFN, first pregnancies are often severely affected and the diagnosis is usually made with the birth of a first affected infant.…”

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The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: a UK national study using three data sources

et al. 2011

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Summary Fetomaternal alloimmune thrombocytopenia (FMAIT) is the most common cause of severe neonatal thrombocytopenia in otherwise well, term infants. First pregnancies are often severely affected. This descriptive, population‐based national study was undertaken in order to inform the case for antenatal screening. Cases were identified using three sources and capture‐recapture techniques used to generate a robust incidence estimate. One hundred and seventy three cases were identified between October 2006 and September 2008. An extra 20 cases were estimated from capture‐recapture analysis, giving an estimated incidence of clinically detected FMAIT of 12·4 cases per 100 000 total births (95%confidence interval: 10·7, 14·3). Fifty‐two cases (30%) were known at the start of pregnancy; 120 (70%) were unknown (n = 115) or unrecognized (n = 5). Unknown cases were more likely to experience a haemorrhagic complication (67% vs. 5%) (P < 0·001) and more likely to have an intracranial haemorrhage (20% vs. 4%) (P = 0·014) than known cases receiving antenatal management. In view of the incidence of severe disease identified, further assessment of the case for antenatal screening is important. There were a number of cases in which the significance of a history of FMAIT in a previous sibling was not recognized and there is a need to raise awareness of the importance of this diagnosis.

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