Experimental Allergic Thyroiditis (and Parathyroiditis) in Neonatally Thymectomized and Bursectomized Chickens. Participation of the Thymus in the Development of Disease

Janković, Branislav D.; Isvaneskí, M; Popesković, Ljiljana; Mitrocic, K

doi:10.1159/000229543

Cited by 42 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autoimmune diseases can be produced in chickens, as they are in mammals, by experimental immunization with the appropriate antigen. For example, immunization with myelin basic protein plus complete Freund's adjuvant produces autoimmune encephalomyelitis in chickens, whereas immunization with thyroglobulin plus the same adjuvant produces autoimmune thyroiditis comparable in appearance to that induced by similar immunization of mice or rats (Jankovic and Isvaneski, 1963;Jankovic et al, 1965). The largest quantity of research, however, has utilized spontaneous models of autoimmune disease in the chicken.…”

Section: Introductionmentioning

confidence: 99%

Avian Models of Autoimmune Disease: Lessons from the Birds

Rose

1994

Poultry Science

View full text Add to dashboard Cite

Many important lessons have been learned from studies of autoimmune diseases in chicken models. It is now quite clear that both cellular and humoral immune responses are important in developing the final picture of autoimmune disease. In the case of the amelanosis of Smyth line (SL) chickens, antibody appears to play the primary role, whereas the sclerosis of University of California/Davis line-200 (UCD-200) birds is mainly mediated by T cells. Chronic thyroiditis of the OS chicken is due to both humoral and cellular effector mechanisms. The Obese strain (OS) chicken is particularly valuable for studies of genetics. Multiple genetic factors converge in producing maximal susceptibility to the development of autoimmune thyroiditis. They include MHC genes responsible for immune recognition; genes affecting thymus development, critical for regulation of the immune response; and genes that control thyroid function, influencing the vulnerability of the target organ to autoimmune attack. The importance of environmental factors, such as dietary iodine, is also strongly supported by studies in the OS chicken. Thus, the birds have provided valuable clues to our understanding of human autoimmune disorders in the past and are expected to do so in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

Avian Models of Autoimmune Disease: Lessons from the Birds

Rose

1994

Poultry Science

View full text Add to dashboard Cite

show abstract

“…Neonatal thymectomy has also been reported\to reduce the frequency of experimentally induced LT in the guinea pig 18 and White Leghorn chicken. 19 In contrast to these observations, neonatal thymectomy in the Obese strain chicken increased 20 and neonatal bursectomy decreased 21 the severity of spontaneous thyroiditis while treatment with antilymphocyte serum had no effect on the severity of the thyroiditis. 22 In the outbred Wistar rat, T-cell depleted produced by thymectomy shortly after weaning followed by whole body irradiation resulted in the occurrence of LT and serum antithyroglobulin antibodies in approximately 60% of treated rats.…”

Section: Discussionmentioning

confidence: 84%

Lymphocytic Thyroiditis and Diabetes in the BB/W Rat: A New Model of Autoimmune Endocrinopathy

Sternthal

Sarantis

et al. 1981

Diabetes

View full text Add to dashboard Cite

SUMMARYThe Bio Breeding/Worcester (BB/W) rat develops spontaneous insulin-dependent diabetes mellitus secondary to lymphocytic infiltration and destruction of the pancreatic beta-cells. This destructive process in the pancreas has been postulated to be based on a thymus-dependent cell-mediated autoimmune process. In view of the well recognized association in man of diabetes mellitus and another autoimmune endocrinopathy, chronic thyroiditis (Hashimoto's thyroiditis), the present studies were carried out to determine whether lymphocytic thyroiditis occurred with increased frequency in the diabetic, insulin-treated BB/W rat. The incidence of lymphocytic thyroiditis was strikingly increased in 8-10-mo-old diabetic rats (59%) as compared with their nondiabetic cohorts (11%) (P < 0.001). Relative thyroid weight was significantly greater in diabetic as compared with nondiabetic rats (P < 0.01) and in diabetic rats with thyroiditis than in diabetic rats without thyroiditis (P < 0.025). Lymphocytic thyroiditis was not accompanied by any consistent changes in serum T 4 , T 3 , and TSH concentrations or in the serum TSH response to thyrotropin-releasing hormone (TRH) suggesting that the thyroiditis was not of sufficient severity or duration to induce primary thyroid gland failure. The BB/W rat represents the first animal model of multiple autoimmune endocrinopathies and provides a unique opportunity to study the pathogenesis of these disorders. DIABETES 30:1058-1061, December 1981. The Bio Breeding/Worcester (BB/W) rat develops spontaneous insulin-dependent diabetes mellitus. Lymphocytic infiltration and destruction of the pancreatic beta-cells occurs in approximately 30% of BB/W rats between 60 and 120 days of age.

show abstract

“…108,109 In 1968, Lupulescu and co-workers 110 produced lymphocytic and plasma cell infiltration and atrophy of the parathyroid glands and adrenal cortex in dogs immunized with extracts of allogeneic parathyroid tissue. In 1974, passive immunization of rats with antiserum against their parathyroid tissue caused a marked immunoparathyroiditis, but without hypoparathyroidism.…”

Section: Pathogenesismentioning

confidence: 99%

Autoimmune Hypoparathyroidism

Whyte

2015

The Parathyroids

View full text Add to dashboard Cite

Experimental Allergic Thyroiditis (and Parathyroiditis) in Neonatally Thymectomized and Bursectomized Chickens. Participation of the Thymus in the Development of Disease

Cited by 42 publications

References 13 publications

Avian Models of Autoimmune Disease: Lessons from the Birds

Avian Models of Autoimmune Disease: Lessons from the Birds

Lymphocytic Thyroiditis and Diabetes in the BB/W Rat: A New Model of Autoimmune Endocrinopathy

Autoimmune Hypoparathyroidism

Contact Info

Product

Resources

About