Experimental Allergic Uveitis : Homologous Retina as Uveitogenic Antigen

Autoimmune Uveo-Retinitis in the Rat Sensitized with Retina Photoreceptor Cell Antigen

“…Species variations in the nature of ocular lesions evoked with retina antigen have been observed in guinea pigs [1,5,6], rabbits [1,3,6], chickens [11], and monkeys [4], and can be correlated with species differ ences in intraocular vascularization, particularly the degree to which the retina is vascularized. These observations suggest that the hematogenous pathway by which the inflammatory infiltrates reach the ocular target area may be implicated in mechanisms of the disease as a determinant of the ocular manifestations.…”

“…The term experimental allergic uveitis was introduced in 1965 to de scribe the autoimmune ocular disease produced in the guinea pig by sensi tization with homologous retina [5], Although the possibility was raised that this anomaly may be due to antigens shared by uvea and retina [1,5], subsequent studies established that the pathogenic antigen is retina specific [6,7,9], and is a protein constituent of the retina located in the photoreceptor cell layers [2,10], These findings have raised questions concerning the mechanisms by which sensitization to retina antigen re sults in uveitis.…”

Bowman lecture on the role of inflammation in degenerative disease of the eye

“…SO can be regarded as the first autoimmune disease, known for centuries as a consequence of war injures and first reported in the English language in a clinico-pathological description by Mackenzie 2 even before Immunology as a discipline was born. It was not for another century or more, however, with the use of Bowman's 'lower' animal models, that the nature of ocular autoantigen(s) was discovered 3,4 and the pathogenic mechanisms of intraocular inflammation (IOI), or more commonly uveitis, began to be unravelled (reviewed in Caspi 5 ).…”

An Essential Role for Death Receptor 3 in Experimental Autoimmune Uveoretinitis

“…8 Experimental autoimmune uveoretinitis (EAU) is an organ-specific, CD4 + T-cell-mediated disease that targets the retina. 9 Studies in EAU have provided abundant evidence that members of the tumor necrosis factor superfamily play pivotal roles in the pathogenesis of intraocular inflammation and retinal tissue destruction.…”

“…Spleens were removed and splenocytes were extracted, seeded at 1 × 10 6 /mL, and stimulated with a range of concentrations of IRBP [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] (0.01-1 µg/mL) for 72 h. For the last 16 h, cells were pulsed with 0.5 µCi 3 [H]thymidine (Amersham Biosciences) and uptake was measured using a beta counter (Wallac, Perkinelmer). PBS/2% DMSO and 2.5 µg/ mL Con A (Concavalin A, Sigma) were used as negative and positive controls, respectively.…”