Experimental amniotic fluid embolism in rabbits

Spence, Michael R.; Mason, K. G.

doi:10.1016/0002-9378(74)90261-0

Cited by 29 publications

(9 citation statements)

References 12 publications

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“…The material that embolizes to the pulmonary vasculature includes not only amniotic fluid, but also fetal squames, lanugo hairs, meconium, fat, mucin, and bile (202). The amniotic fluid itself does not appear to playa major role in the pathogenesis of this syndrome, because intravenous infusion of fresh, autologous amniotic fluid into pregnant rabbits or rhesus monkeys has) been shown to be innocuous (204,205). Rather, it is presumably one of the many contaminants, either of fetal or placental origin, that initiates the clinical syndrome.…”

Section: Amniotic Fluid Embolismmentioning

confidence: 99%

“…These include: (1) tumultuous labor, (2) use of uterine stimulants, (3) the presence of meconium in the amniotic fluid, (4) advanced maternal age, (5) multiparity, and (6) intrauterine fetal death (202)(203)(204)(205)(206). Courtney and co-workers (207) have suggested that the association with intrauterine fetal death may be related to increased permeability and friability of fetal membranes.…”

Section: Amniotic Fluid Embolismmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy and The Lung^1,²

Se¹,

St²,

Cohen³

et al. 1980

Am Rev Respir Dis

308

110

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Section: Amniotic Fluid Embolismmentioning

confidence: 99%

Section: Amniotic Fluid Embolismmentioning

confidence: 99%

Pregnancy and The Lung^1,²

Se¹,

St²,

Cohen³

et al. 1980

Am Rev Respir Dis

308

110

View full text Add to dashboard Cite

“…6 De même, lors d'expérimentation animale, l'injection de liquide amniotique dans la circulation sanguine ne provoque pas constamment une symptomatologie d'EA. 7 Un mécanisme immunologique a été également discuté par Clark et coll., La plupart des observations d'EA font état de grandes catastrophes obstétricales. Le diagnostic d'EA est avant tout un diagnostic clinique.…”

Section: Discussionunclassified

Embolie amniotique compliquant une interruption médicale de la grossesse

Kaaniche

Chaari

Zekri

et al. 2016

Can J Anesth/J Can Anesth

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RésuméContexte L'embolie amniotique est toujours une complication grave et survient généralement pendant le travail ou tout de suite après la naissance de l'enfant. É léments cliniques Nous rapportons le cas d'une patiente victime d'une embolie amniotique au décours d'une interruption médicale de la grossesse à 24 semaines d'aménorrhée suite à la découverte d'un foetus porteur de tératome. Le diagnostic d'embolie amniotique était fortement suspecté devant l'installation immédiate après l'accouchement d'une hypotension artérielle profonde, d'une détresse respiratoire hypoxique, d'un état de coma et d'une coagulopathie intravasculaire disséminée. Des examens complémentaires ont été réalisés pour étayer le diagnostic: l'étude cytologique du prélèvement veineux périphérique et du liquide de lavage broncho-alvéolaire maternel, le dosage sanguin de la tryptase et de l'alphafoetoprotéine et la recherche de la protéine de liaison au facteur de croissance insulinomimétique 1. Conclusion L'embolie amniotique est un diagnostique rare et difficile surtout lors de situations inhabituelles mais qui peut être facilité par la recherche sérique de marqueurs amniotiques et de la tryptase. AbstractBackground Amniotic fluid embolism is always a severe complication and generally occurs during labour or immediately after childbirth. Clinical featuresWe report the case of a patient falling victim to amniotic fluid embolism after the medical termination of her pregnancy at 24 weeks of amenorrhea following the discovery of a teratoma-carrying foetus. The amniotic fluid embolism diagnosis was strongly suspected in the face of the sudden onset of severe arterial hypotension, hypoxic respiratory distress, a coma state and disseminated intravascular coagulopathy immediately after the delivery. Additional tests were conducted to support the diagnosis: cytological testing of a peripheral venous sample and maternal broncho-alveolar lavage fluid, dosing of tryptase and alpha-fetoprotein levels as well as screening for insulin-like growth factor binding protein 1. Conclusion Amniotic fluid embolism is a rare and difficult diagnosis, especially in unconventional settings, yet it can be facilitated by screening for amniotic markers and tryptase.

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“…However, Lee et al [13] demonstrated that fetal cells can be found in the blood of normal parturient women and that they did not produce clinical symptoms similar to those of AFE. Other investigators have reported an inability to reproduce the AFE in animal models by injection of amniotic fluid directly into circulation [14]. Clark et al [12] demonstrated that AFE is a type of anaphylactic shock related to various cytokines and immunological factors.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the bispectral index during cardiopulmonary resuscitation -A case report-

Jung

Kim

2013

Korean J Anesthesiol

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The usefulness of using the bispectral index (BIS) for monitoring during cardiopulmonary resuscitation (CPR) is not clearly understood. However, BIS has been a popular anesthetic monitoring device used during operations. The case presented is of a pregnant woman going into cardiac arrest due to an amniotic fluid embolism during a Cesarean section. CPR was performed, but neither the return of spontaneous circulation (ROSC) nor the return of consciousness was achieved, despite 50 min of effective CPR. However, CPR was continued based on BIS. ROSC was achieved, and an alert consciousness state was reached 1 day postoperation. This finding suggests that BIS be used as a basic monitoring device during CPR and that it may help in deciding to continue CPR.

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Experimental amniotic fluid embolism in rabbits

Cited by 29 publications

References 12 publications

Pregnancy and The Lung^1,²

Pregnancy and The Lung^1,²

Embolie amniotique compliquant une interruption médicale de la grossesse

Usefulness of the bispectral index during cardiopulmonary resuscitation -A case report-

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Experimental amniotic fluid embolism in rabbits

Cited by 29 publications

References 12 publications

Pregnancy and The Lung1,2

Pregnancy and The Lung1,2

Embolie amniotique compliquant une interruption médicale de la grossesse

Usefulness of the bispectral index during cardiopulmonary resuscitation -A case report-

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Pregnancy and The Lung^1,²

Pregnancy and The Lung^1,²