Experimental Anæmias in the Rabbit

Bunting, C. H.

doi:10.1084/jem.8.5.625

Cited by 27 publications

(7 citation statements)

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“…In size they resembled normal, unnucleated blood corpuscles. Bunting (7) has compared the blood picture in a rabbit rendered anemic through repeated hemorrhages with that of ricin and saponin poisoning. He found 15 normoblasts per c. ram.…”

Section: (From the Laboratory Of Physiology Of The Harvard Medical Scmentioning

confidence: 99%

The Factors Concerned in the Appearance of Nucleated Red Blood Corpuscles in the Peripheral Blood

Drinker

Kreutzmann

1918

Journal of Experimental Medicine

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In a previous paper the authors (1) have shown that the appearance of nucleated red corpuscles in the peripheral circulation is independent of the increased blood flow produced by exercise or by vasomotor paralysis. A slight increase in the number of these ceils may be obtained, but one which, when thoroughly analyzed, never gives the picture of a true normoblast crisis. In the same paper it was said that the experiments on increased blood flow were designed to control more radical perfusion experiments by means of which cellular extrusion from the marrow could be studied directly. The interesting feature of norrnoblast appearance is its relation to blood regeneration, its reliability as an index of new formation. Perfusion work upon the marrow cannot be carried through a long enough period to give direct evidence of blood regeneration through increased red cell counts. It is therefore necessary to make use of the appearance of nucleated red cells as indicating the operation of stimuli for regeneration, provided this appearance can be shown to be an acute and reliable reaction.In addition to a further demonstration of the fact that increased blood flow through the bone marrow has in itself no influence upon * The expense of this research was in part defrayed by a grant from the Bache

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Section: (From the Laboratory Of Physiology Of The Harvard Medical Scmentioning

confidence: 99%

The Factors Concerned in the Appearance of Nucleated Red Blood Corpuscles in the Peripheral Blood

Drinker

Kreutzmann

1918

Journal of Experimental Medicine

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“…The leukoblastic and erythroblastic centers, as described by Bunting (16), and the platelet formation as described by Wright (17), can be made out easily. The number of megakaryocytes appears to be extremely variable.…”

Section: Bone Marrowmentioning

confidence: 99%

The Pathological Effects of Atmospheres Rich in Oxygen

Karsner

1916

Journal of Experimental Medicine

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In spite of numerous abnormalities or non-experimental lesions in the rabbit certain facts can be considered as established. It has been known for many years that pneumonia is produced by the more or less prolonged inhalation of high partial pressures of oxygen. The studies herein reported show that atmospheres containing 80 to 96 per cent oxygen under normal barometric pressure produce in 24 hours, or more commonly 48 hours, congestion, edema, epithelial degeneration and desquamation, fibrin formation, and finally a pneumonia, probably of irritative origin and to be described as a fibrinous bronchopneumonia. The important new points are the time relations of these changes and definition of the type of the pneumonia. Other studies have noted slight passive congestion, but it is now established that this is to be accounted for in most cases by dilatation of the right side or of both sides of the heart. This congestion affects all the abdominal viscera and is accompanied by certain secondary changes such as cloudy swelling of the parenchymatous organs and phagocytosis of erythrocytes by endothelial cells of the mesenteric lymph nodes. Although deficiency of oxygen may affect the hematopoietic system, the animals subjected to high oxygen percentages failed to show any demonstrable pathologic changes in blood, spleen, lymph nodes, or bone marrow, except for the presence of congestion. This study is the first of a comprehensive series projected in and under the direction of the Carnegie Nutrition Laboratory. Different animals and various methods of attack will be employed in the investigation.

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“…The intravenous injection of saponin has been shown to cause rapid injury to the endothelium lining the sinusoids in the bone marrow of rabbits, resulting in normoblastemia and large scale hemorrhage in the bone marrow (Bunting, 1906;Omura and Osogoe, 1951;Argano et al, 1969;Oberling, et al, 1973;Endo, 1977;Hoshi and Weiss, 1979).…”

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confidence: 99%