Experimental analysis and biaxial biomechanical behaviour of ex-vivo sheep trachea

Abstract

PurposeThe purpose of this study is to investigate the mechanical behaviour of the tracheal tissue under biaxial tensile loading. Furthermore, the study examines the material properties of the tissue through a study of the model parameters for six constitutive models.Materials and methodsThe fourteen (n = 13) trachea sheep (Vleis Merino) pieces of tissues measured to be ~ 30 × 20 mm where only the effective area subjected to engineering strain was ~ 25 × 16 mm. In this study, we assume that the tracheal tissue is anisotropic and incompressible, therefore we apply and study the material parameters from six models namely the Fung, Choi-Vito, Holzapfel (2000), Holzapfel (2005), Polynomial (Anisotropic) and Four-Fiber Family models.ResultsThe results show that the trachea tissue is twice as stiff along the circumferential direction as it is along the longitudinal direction. It is also observed that the material properties are different (non-homogeneous) along the trachea.ConclusionsThe findings of this study will benefit computational models for the study of tracheal diseases or injuries. Furthermore, these findings will assist in the development of regenerative medicine for different tracheal pathologies and in the bioengineering of replacement tissue in cases of damage.

Microstructure and Mechanics of the Bovine Trachea: Layer Specific Investigations Through Shg Imaging and Biaxial Testing

“…This would in turn ensure the proper fiber kinematics influencing the tissue's mechanical response. To the best of our knowledge only one study has been reported to have conducted biaxial tension testing on tracheal tissue (Nemavhola et al, 2021). However, they do not test individual tissue layers, thus upholding the novelty of our test results.…”