Experimental Analysis of Genetic Determinants in Resistance to Infectious Disease*

Gowen, John W.

doi:10.1111/j.1749-6632.1961.tb31101.x

Cited by 11 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The type of susceptibility that is inherited in C-HS individuals is different from that which has been generally described previously. In the majority of previous reports susceptibility or resistance to one organism did not indicate susceptibility or resistance to another unless the two organisms were closely related (Gowen, 1961). Furthermore, this generalisation applies to both viral and bacterial diseases.…”

mentioning

confidence: 93%

Comparative studies of susceptibility to infection in the Chediak‐Higashi syndrome

et al. 1968

View full text Add to dashboard Cite

mentioning

confidence: 93%

Comparative studies of susceptibility to infection in the Chediak‐Higashi syndrome

et al. 1968

View full text Add to dashboard Cite

“…The genetic control of immunity to H. dtelli in deer-mice therefore appears to have a different basis from that of immunity to T. muris in Schofield mice. The situation in the latter system is paralleled more closely by that in albino rats infected with Brugia pahangi (Sucharit & MacDonald, 1973) and shows overall similarity to that in laboratory mice infected with species of Salmonella (Webster, 1933;Gowen, 1961). A particular point of similarity is that Webster found effective separation of susceptibility to S. enteriditis to occur within the first two selection generations; separation of resistance occurred within the first generation.…”

Section: Discussionmentioning

confidence: 84%

Genetic control of immune responses to parasites: selection for responsiveness and non-responsiveness to Trichuris muris in random-bred mice

Wakelin

1975

Parasitology

View full text Add to dashboard Cite

Populations of Schofield strain, random-bred mice were shown to have a bimodal variation in ability to bring about immune expulsion of the nematode Trichuris muris. This variation was genetically determined and independent of the size of infection experienced. The proportion of mice unable to achieve worm expulsion (non-responders) was relatively constant in various populations of the strain but was increased by selective breeding from mice of known status. Crosses made between non-responder and responder mice produced progeny that were almost all (92%) of responder phenotype, showing that the ability to achieve worm expulsion was inherited as a dominant characteristic. It is suggested that the genetic control involves a small number of genes; the possible immunological mechanisms by which control is mediated are briefly discussed.

show abstract

“…Genetically determined resistance or susceptibility to infectious disease has been recognized for many years and has been extensively investigated in a number of experimental models (Gowen, 1948(Gowen, , 1961. The mechanisms underlying such genotypic control have been the subject of much speculation, but a realistic basis has been provided by the recent identification of specific immune response genes, which determine, in an all-or-nothing manner, the ability of an animal to respond to particular antigens (McDevitt & Benacerraf, 1969) and by the demonstration that the level of certain antibody responses is under relatively simple polygenic control (Biozzi, Stiffel, Mouton, Bouthillier & Decreusefond, 1971).…”

Section: Introductionmentioning

confidence: 99%

Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice

Wakelin

1975

Parasitology

View full text Add to dashboard Cite

A comparison has been made of the responses of random-bred CFLP and inbred NIH mice to infection with Trichuris muris. Random-bred mice showed greater variation in worm burdens and less uniformity in worm expulsion. Irradiation prior to infection reduced variation, but did not increase the mean level of infection above that shown by the most susceptible unirradiated mice. In NIH mice, however, irradiation raised the level of infection in all mice. The factors responsible for variation between CFLP mice and for the level of infection in NIH mice came into play after the fifth day of infection and were inactivated by cortisone acetate. It is suggested that these factors are immunologically mediated and under direct genetic control. Uniformity of infection and expulsion in NIH mice is therefore seen as a consequence of genetic uniformity; variability in CFLP mice as a consequence of genetic variation.The time of worm expulsion was found to differ markedly between inbred strains of mice. Hybrid progeny showed the expulsion time characteristic of the parental strain with the most rapid expulsion; greater resistance was therefore inherited as a dominant characteristic. The genetic control of immunity to T. muris is discussed in the context of the antibody- and cell-mediated components of the expulsion process.

show abstract

Experimental Analysis of Genetic Determinants in Resistance to Infectious Disease*

Cited by 11 publications

References 31 publications

Comparative studies of susceptibility to infection in the Chediak‐Higashi syndrome

Comparative studies of susceptibility to infection in the Chediak‐Higashi syndrome

Genetic control of immune responses to parasites: selection for responsiveness and non-responsiveness to Trichuris muris in random-bred mice

Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice

Contact Info

Product

Resources

About