LOX/LCH4 rocket engine has been recognized as the ideal power choice for future space vehicles due to the merits of low cost, non-toxic and pollution-free, convenient maintenance, suitable for reuse and high specific impulse. In the process of wide range variable thrust of LOX/LCH4 rocket engine, the coolant methane is in a subcritical state due to the low combustor pressure under low operation conditions. The instability of two-phase flow is easy to occur in regenerative cooling channel (RCC), and it is urgent to investigate the heat transfer performance of methane with phase change in RCC. Experiments have been conducted to investigate the flow boiling characteristics of liquid methane in the single mini channels with the diameters of 1.0, 1.5 and 2.0 mm. Effects of the mass flux (266.75~1781.26 kg/m2·s), inlet pressure (0.56~4.24 MPa), heat flux (53.25~800.07 kW/m2) and channel diameter (1.0~2.0 mm) on the flow boiling heat transfer coefficients are tested. Results show that there are two regions with different heat transfer mechanism, one is the nucleate boiling dominated region for low mass quality and the other is the convection evaporation dominated region for high mass quality. A new correlation expressed by Bo, We, Kp, X, Co, Ftg is proposed, which yields good fitting for 355 experimental data with a mean absolute error (MAE) of 10.9%. Present experimental results can provide reference for the thermal protection prediction and optimal design of RCC in LOX/LCH4 rocket engine.