Experimental Analysis of Pressure and Flow Alterations During and After Insertion of a Multilayer Flow Modulator into an AAA Model with Incorporated Branch

Tupin, Simon; Takase, Kei; Ohta, Makoto

doi:10.1007/s00270-021-02835-z

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…where µ is the fluid dynamic viscosity, and k, the permeability of the porous medium. In contrast, the pressure drop between the aortic inlet and the aneurysm was found low and similar in all cases: intra-aneurysmal flow velocity is reduced after deployment of MFM devices as seen in our previous study [17].…”

Section: Flow Rate and Pressure Evaluation Reveal Branch Perfusion Pr...supporting

confidence: 76%

“…A previously reported experimental system [17] was adapted for this infrarenal AAA model (Figure 2a).…”

Section: Circulation Systemmentioning

confidence: 99%

“…A previously reported experimental system [17] was adapted for this infrarenal AAA model (Figure 2a). A mixture of glycerin, sodium iodide and distilled water was used as blood mimicking fluid (BMF) in order to reproduce the rheological properties of blood and match the reflective index of the silicone model [20].…”

Section: Circulation Systemmentioning

confidence: 99%

“…PIV was found to be ideal to locally analyze flow pattern and velocity modifications occurred after endovascular treatment. Our previous study focused on intra-aneurysmal flow modification after MFM deployment [17].…”

Section: Introductionmentioning

confidence: 99%

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Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

Tupin

Takase

Ohta

2022

Fluids

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Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure.

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Section: Flow Rate and Pressure Evaluation Reveal Branch Perfusion Pr...supporting

confidence: 76%

“…A previously reported experimental system [17] was adapted for this infrarenal AAA model (Figure 2a).…”

Section: Circulation Systemmentioning

confidence: 99%

Section: Circulation Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

Tupin

Takase

Ohta

2022

Fluids

Self Cite

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“…The multilayer ow modulator (MFM) was originally a consumable material for the treatment of the abdominal aortic aneurysm. Its main advantage is the avoidance of the revascularisation and blockage of branch vessels, by guiding the blood ow into the branches [17]. Some clinicians have tried to treat the diseases of the descending aorta, aortic arch, and even the ascending aorta with good clinical results [18-19-20].…”

Section: Introductionmentioning

confidence: 99%

Effects of two different surgical methods for endovascular repair of the thoracic aorta on the hemodynamics of the left subclavian artery

Li,

Yuan,

Wen

et al. 2023

Preprint

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Background: Some clinicians use endograft to partially cover the left subclavian artery (LSA) ostium or multilayer flow modulator (MFM) to mitigate cases with an insufficient landing area in thoracic endovascular aortic repair(TEVAR) treatment. So we used computational fluid dynamics (CFD) to study the effects of two surgical methods on the hemodynamics of the LSA, due to they may affect the long-term patency rate of the LSA. Methods: The digital model of the aortic arch was established and named model A, which only included supraarch branch the LSA. The simulated digital model of the MFM was implanted into model A, named as model B. By directly covering one half of the LSA ostium, which was named as model C. All established models were imported into the Gambit grid division software for grid division and were subsequently imported into the Fluent software for hemodynamic numerical simulation and calculation. The changes in the related hemodynamic parameters of the LSA after implantation of the two stents were analyzed and compared. Results: Under the same aortic inlet flow, in model C, the lumen flow of the LSA was obviously reduced and the distal descending aorta flow was increased, the local blood flow velocity of LSA ostium increased and whole blood flow velocity at the distal end decreased. The average wall shear stress(WSS) of the LSA was significantly decreased. Meanwhile there was an obvious turbulent flow in the LSA lumen, and the related blood flow state was disordered. However, all changes in model B was occured, they changed slightly compared with model A. Conclusion: CFD research confirmed that the implantation of an MFM had little influence on the hemodynamics of the LSA. In contrast, the implantation of an endograft partially covering the LSA ostium increased the local ostium velocity. But it reduced the global flow rate, velocity, and average wall shear stress at the distal end. This change is likely to cause a long-term hardening and an acute thrombosis of the LSA artery. Nevertheless, this operation can also be used in specific clinical cases.

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Hämodynamische Auswirkungen des Multilayer-Flow-Modulator auf ein Aortenaneurysma

2021

Gefäßmedizin Scan - Zeitschrift für Angiologie, Gefäßchirurgie,

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Experimental Analysis of Pressure and Flow Alterations During and After Insertion of a Multilayer Flow Modulator into an AAA Model with Incorporated Branch

Cited by 4 publications

References 34 publications

Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment

Effects of two different surgical methods for endovascular repair of the thoracic aorta on the hemodynamics of the left subclavian artery

Hämodynamische Auswirkungen des Multilayer-Flow-Modulator auf ein Aortenaneurysma

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