This study aims to evaluate the mechanical behavior, by ways of the FEM, of three femoral stems made of a Ti-6Al-4V titanium alloy with transverse holes in the proximal zone and a stem made of a β-type titanium alloy with a stiffness varying from 65 GPa in the proximal zone to 110 GPa in the distal zone and the CFRP composite material. The purpose of the study was to evaluate the effect of stress shielding on an intact femoral bone. A three-dimensional model of the intact femur was created, and the three prostheses were inserted with perfect stem bone fit. Applying constraint conditions such as fixation in all directions of the distal part of the femur and the application of a static load simulating standing still during a gait cycle allowed the stresses of both the implants and the bone to be compared. Evaluating the stress shielding for the three proposed materials was possible by identifying the seven Gruen zones. We can see from the results obtained that the metal alloys produced observable stress shielding in all the Gruen zones. There was a difference for the β-type alloy which, as a result of its stiffness variation from the proximal to the distal zone, did not show any level of stress shielding in Gruen zones 1 and 2. The CFRP composite, in contrast, showed no stress shielding in all of the Gruen zones and is an excellent material for the fabrication of total hip replacements. Further in vitro and in vivo validation studies are needed to make the modeling more accurate and understand the biological effects of the use of the three materials.