Experimental and clinical evaluation of an absorbable biomaterial inducing an anti-adhesive barrier (Divide®)

Merle, M.; Lallemand, B.; Lim, Aymeric; Gantois, Guillaume

doi:10.1007/s00590-008-0294-9

Cited by 7 publications

References 11 publications

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Sugar Functionalization of Silks with Pathway‐Controlled Substitution and Properties

et al. 2021

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Silk biomaterials are important for applications in biomedical fields due to their outstanding mechanical properties, biocompatibility, and tunable biodegradation. Chemical functionalization of silk by various chemistries can be leveraged to enhance and tune these features and enable the expansion of silk‐based biomaterials into additional fields. Sugars are particularly relevant for intracellular communication, signal transduction events, as well as in hydrated extracellular matrices such as in cartilage, vitreous, and brain tissues. Multiple reaction pathways are demonstrated (carboxylation of serines followed by carbodiimide coupling with glucosamine, carboxylation of tyrosines followed by carbodiimide coupling with glucosamine; direct carbodiimide coupling of the inherent carboxylic acids of silk (aspartic and glutamic acid) with glucosamine) for the covalent conjugation of glucosamine onto silk with characterization by proton nuclear magnetic resonance (1H‐NMR), liquid chromatography tandem mass spectroscopy (LC‐MS), water contact angle (WCA), and Fourier transform infrared (FTIR) spectroscopy. The results indicate that different pathways substitute different amounts of glucosamine onto silk chains, with control over resulting material properties, including hydrophobicity/hydrophilicity and biological responses. The aqueous processability of these conjugates into functional material formats (films, sponges) is assessed. These new classes of bio‐inspired materials can lead to multifunctional biomaterials for potential applications in different fields of biomedical engineering.

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Sugar Functionalization of Silks with Pathway‐Controlled Substitution and Properties

et al. 2021

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Integration of cellulases into bacterial cellulose: Toward bioabsorbable cellulose composites

Catchmark

2011

J Biomed Mater Res

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Cellulose biodegradation resulting from enzymolysis generally occurs in nature rather than in the human body because of the absence of cellulose degrading enzymes. In order to achieve in-vivo degradation in human body for in-vivo tissue regeneration applications, we developed a bioaborbable bacterial cellulose (BBC) material, which integrates one or more cellulose degrading enzymes (cellulases), and demonstrated its degradability in vitro using buffers with pH values relevant to wound environments. We introduced a double lyophilizing process to retain the microstructure of the bacterial cellulose as well as the activity of embedded enzymes allowing for long-term storage of the material, which only requires hydration before use. Enzymes and their combinations have been examined to optimize the in-vitro degradation of the BBC material. In-vitro studies revealed that acidic cellulases from Trichoderma viride showed reasonable activity for pH values ranging from 4.5 to 6.0. A commercial cellulase (cellulase-5000) did not show good activity at pH 7.4, but its degrading ability increased when used in conjunction with a β-glucosidase from Bacillus subtilis or a β-glucosidase from Trichoderma sp. Given the harmless glucose product of the enzymatic degradation of cellulose, the BBC material may be ideal for many wound care and tissue engineering applications for the bioabsorbable purpose.

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History and performance of implant materials applied as peritendinous antiadhesives

Bürgisser

Buschmann

2014

J. Biomed. Mater. Res.

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Peritendinous fibrotic adhesions after tendon surgery are still a problem up-to-date. Approaches to overcome or at least minimize adhesion formation include implantation of barrier materials, application of lubricants or combinations of materials and functionalized drugs that are controllably released and support the healing tendon to glide and achieve the full range of motion after regeneration. Although a huge amount of different materials have been experimentally tested, the optimal strategy with respect to material and method has not yet been determined. In this review, we present a historical overview of physical barriers as well as liquid agents that have been used in order to prevent peritendinous adhesion formation. The materials are divided according to their first publication into two time frames; before and after 1980. There is no claim to include all materials tested neither will the "best" material be chosen; however, we present several materials that were experimentally tested in different animal trials as well as in clinical trials in contrast to other materials that were only tested once and disappeared from the assortment of anti-adhesives; which as such is a valuable information about its applicability for this purpose.

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Experimental and clinical evaluation of an absorbable biomaterial inducing an anti-adhesive barrier (Divide®)

Cited by 7 publications

References 11 publications

Sugar Functionalization of Silks with Pathway‐Controlled Substitution and Properties

Sugar Functionalization of Silks with Pathway‐Controlled Substitution and Properties

Integration of cellulases into bacterial cellulose: Toward bioabsorbable cellulose composites

History and performance of implant materials applied as peritendinous antiadhesives

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