1994
DOI: 10.1007/bf02940070
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Experimental and clinical experience with iodine 123-labeled iodophenylpentadecanoic acid in cardiology

Abstract: Iodine 123-labeled iodophenylpentadecanoic acid (IPPA) has been synthesized for investigating myocardial free fatty acid (FFA) metabolism. The diagnostic application of labeled FFA in heart disease may be important, because FFA is the preferred substrate of cardiac energy metabolism at rest in the fasting state. In addition, regional myocardial FFA uptake and regional myocardial blood flow are tightly coupled in normal myocardium with beta-oxidation, which is extremely sensitive to oxygen deprivation. This art… Show more

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Cited by 7 publications
(1 citation statement)
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“…In myocytes, radioiodinated IPPA is esterified to form labeled complex lipids and metabolized by β-oxidation to the predominant metabolite, iodobenzoic acid and other short chain oxidation end-products [11, 12]. In a canine model of regional low-flow ischemia, initial uptake of IPPA was lower in ischemic regions relative to non-ischemic regions, however myocardial clearance rate was significantly slower in ischemic regions leading to relatively increased retention of radioactivity in ischemic myocardium at later intervals [13].…”
Section: Radiopharmaceuticals For Mfao Imagingmentioning
confidence: 99%
“…In myocytes, radioiodinated IPPA is esterified to form labeled complex lipids and metabolized by β-oxidation to the predominant metabolite, iodobenzoic acid and other short chain oxidation end-products [11, 12]. In a canine model of regional low-flow ischemia, initial uptake of IPPA was lower in ischemic regions relative to non-ischemic regions, however myocardial clearance rate was significantly slower in ischemic regions leading to relatively increased retention of radioactivity in ischemic myocardium at later intervals [13].…”
Section: Radiopharmaceuticals For Mfao Imagingmentioning
confidence: 99%