Experimental and Clinical Study of Cobra Venom as an Analgesic

Use of split‐free nano‐liquid chromatography–mass spectrometry/high resolution mass spectrometry interface to improve the detection of α‐cobratoxin in equine plasma for doping control

“…Since this time, the molecule was strongly suspected to be used as an undetectable analgesic substance to relieve horse pain after injuries in the horseracing industry. Snake venoms have been used for decades and the first reported case of cobra venom dedicated to experimental and clinical study of animals and humans started in 1935 . The authors reported remarkable effects produced by injections of cobra venom, particularly the relief of severe pains from patients with malignant tumours.…”

“…Snake venoms have been used for decades and the first reported case of cobra venom dedicated to experimental and clinical study of animals and humans started in 1935. 5,6 The authors reported remarkable effects produced by injections of cobra venom, particularly the relief of severe pains from patients with malignant tumours. The isolation of α-Cbtx or alpha-elapitoxin-Nk2a from venom preparation was first published in 1971.…”

Influence of Indole Acetic, Indole Butyric, and Naphthalene Acetic Acids on Roots of Lupinus Albus Seedlings

“…This action has been discussed by the senior author under the caption of the "four dimensions of pharmacodynamics" (Macht, 1932). For instance, such powerful alkaloids as atropine, morphine, nicotine and aconitine, when adminstered to animals or applied to animal tissues in sufficiently minute doses, effect a stimulation or, as it is often termed, a "therapeutic" action, while in larger doses they act as potent poisons, producing death of organism or tissue.…”

“…For instance, such powerful alkaloids as atropine, morphine, nicotine and aconitine, when adminstered to animals or applied to animal tissues in sufficiently minute doses, effect a stimulation or, as it is often termed, a "therapeutic" action, while in larger doses they act as potent poisons, producing death of organism or tissue. Similarly, it has recently been shown that such a deadly poison as cobra venom is a valuable therapeutic agent when employed in sufficiently small doses (Macht, 1936). Even such a well-known poison as sodium cyanide, for instance, administered in minute doses, may be a useful drug, stimulating the activity of the respiratory center in higher animals instead of effecting the paralysis that follows ingestion of larger doses of the same poison (Lovenhart, 1918).…”

Influence of Indole Acetic, Indole Butyric, and Naphthalene Acetic Acids on Roots of Lupinus albus Seedlings

“…For instance, such powerful alkaloids as atropine, morphine, nicotine and aconitine, when adminstered to animals or applied to animal tissues in sufficiently minute doses, effect a stimulation or, as it is often termed, a "therapeutic" action, while in larger doses they act as potent poisons, producing death of organism or tissue. This action has been discussed by the senior author under the caption of the "four dimensions of pharmacodynamics" (Macht, 1932). Even such a well-known poison as sodium cyanide, for instance, administered in minute doses, may be a useful drug, stimulating the activity of the respiratory center in higher animals instead of effecting the paralysis that follows ingestion of larger doses of the same poison (Lovenhart, 1918).…”