In this study, an environment-friendly, energy-saving, and useful synthesis of zinc oxide (ZnO) nanoparticles (NPs), titanium oxide (TiO 2 ) NPs, and mixed Zn/TiO x -NPs was achieved using underwater pulse discharge plasma. The obtained NPs were characterized by UV spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. In the discharge cell, the viscose patch is impregnated with ZnO, TiO 2 , and mixed Zn/TiO x -NPs in a one-step process. The adhesive patch is effective against Escherichia coli, Staphylococcus albicans, and Bacillus subtilis. The viscose patch containing 0.22% Zn/TiO x -NPs demonstrated the highest antimicrobial activity. These antimicrobial patches can be used to treat and cover wounds susceptible to infection. K E Y W O R D S antimicrobial patches, mixed Zn/TiO x nanoparticles, plasma, wound therapy