Experimental Shack-Hartmann wavefront sensor (SHWFS) measurements were collected for a laser beam that propagated through a weakly compressible shear layer. Complementary computational fluid dynamics (CFD) was also conducted to match the experiment. The path-integrated CFD results were then applied to a SHWFS model such that the experimental and CFD results could be compared. Using both the experimental and CFD wavefront results, it was found that, although the CFD results slightly overestimated the resultant wavefront error, the CFD and experimental results revealed extremely similar wavefront topology. In order to further examine the aberrations imposed onto the laser beam in both datasets, the SHWFS image-plane irradiance patterns and circulation of phase gradients were studied. Similar to the overall wavefront topology, these data reduction approaches revealed similar phenomena in both the experimental and CFD-modeled results. Specifically, appreciable circulation and beam spread of the SHWFS image-plane irradiance patterns were exhibited throughout the shear layer's braid region. Both of these findings suggest that sharp phase gradients exist in the weakly compressible shear layer and both (1) the SHWFS resolution and (2) the continuous nature of the phase estimate obtained using SHWFS data in a least-squares reconstruction algorithm make these phase gradients challenging to resolve. The findings presented here inform efforts looking to experimentally or computationally study aero-optical environments.