Experimental and computational study of naphthalimide derivatives: Synthesis, optical, nonlinear optical and antiviral properties

Kumar, Santosh; Muhammad, Shabbir; Alarfaji, Saleh S.; Yoon, Sanghyun; Kim, Minse; Youm, Keechul; Khalid, Muhammad; Chaudhry, Aijaz Rasool; Koh, Joonseok

doi:10.1016/j.ijleo.2021.167748

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…Naphthalimides are a category of chemical compounds which can be used as fundamental frameworks in antiprotozoal, antiinflammatory, antiviral, and anticancer medicines, among other applications. [ 143 ] The tricyclic planar ring system of the naphthalimide category have a crucial role in its intercalation with DNA to disrupt biological processes; the motif's substitution sequence also extends to a number of other purposes. [ 144 ] Numerous naphthalimide analogues were identified in the literature as having interesting anti‐tumor properties with variable potency.…”

Section: Nitrogen Containing Heterocycles As Inhibitors Of Topoisomer...mentioning

confidence: 99%

Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates

Sahu

Chaurasiya

Chawla

2022

Journal of Heterocyclic Chem

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Cancer is a broad word for a set of diseases that can begin in virtually any organ or tissue of the body and spread to other organs. In 2020, cancer was the largest cause of death worldwide, accounting for 10 million fatalities, or one in every six deaths. Nitrogen containing heterocyclic compounds are a massive research focus because it has a unique position and is a cherished source of a wide range of bioactive molecules in medicinal chemistry. Over 75% of the currently accessible market is covered by FDA-approved drugs containing nitrogen moieties. DNA topoisomerase II is a reassuring approach for novel anticancer heterocyclic medicines because it plays a crucial role in DNA metabolism, replication, recombination, and repair. Given the importance of topo II in chemotherapy, there is a pressing necessity to boost topo II or multitarget topo II inhibitors in order to combat drug resistance and minimize toxicity. Following the trend of researching the advancement of effective topo II inhibitors with minimal toxicity, the current review article consolidates a detailed account of nitrogen-containing heterocyclic compounds and categorizes them into different classes based on structural characterization, such

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Section: Nitrogen Containing Heterocycles As Inhibitors Of Topoisomer...mentioning

confidence: 99%

Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates

Sahu

Chaurasiya

Chawla

2022

Journal of Heterocyclic Chem

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“…This adaptability has led to extensive applications in several fields, ranging from selective ion probes and colorful dyes but also in the pharmacological field [12][13][14][15][16]. Several studies reported that compounds which contain a naphthalimide-core scaffold present increased bioactivity, allowing for its usage as an antitumor [17], antidepressant [18], antiviral [19], antiprotozoal [20], anti-inflammatory [21], anti-tuberculosis [22] and antibacterial agent [13]. This increased bioactivity is mainly due to its DNA-binding mechanisms, which are mostly derived from the tricyclic planar ring configuration of the naphthalimide scaffold [12].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Polymers for Environmental Monitoring: Targeting Pathogens and Metal Contaminants with Naphthalimide Derivatives

Galhano,

Kurutos,

Dobrikov

et al. 2024

Preprint

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The continuous monitoring of Hg2+ levels in aqueous environments is crucial to assess a potential indication of methylmercury contamination via bacterial conversion, yet existing methods often require extensive sample treatment, expensive equipment, and transportation to a specialized facility. To mitigate this issue, this study introduces the synthesis and application of three naphthalimide-based compounds with significant fluorescent and solvatochromic behaviour (C1, C2 and C3) for the detection of mercury ions, with an inherent associated antibacterial activity, creating a dual-functionality material. The incorporation of these compounds into polymers, such as polyvinyl chloride (PVC), poly (methyl methacrylate-co-methacrylic acid) (PUMA), and starch, allowed for the development of solid-support sensors/surfaces with a strong antibacterial profile, highlighting the inherent dual-functionality of the compounds. Most interestingly, the C2-doped starch biopolymer allowed for the detection of Hg2+ ions at concentrations as low as 2 ppm in an aqueous environment through a rapid, on-site evaluation without the need for sample treatment. This biopolymer was constructed following a sustainable, green-chemistry-oriented, temperature-dependent water/starch synthetic route, without the addition of plasticizers, and without any associated ecotoxicity. The study promotes the use of sustainable methods for environmental monitoring and antibacterial applications, advancing material science to offer effective, accessible, and eco-friendly solutions for detecting and mitigating mercury pollution and bacterial contaminations, enhancing environmental and health safety.

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“…As virus effect is still on rise, there is an urgent need to develop effective drug to control the mortality rate which may rise in near future. A number of literatures are published exploring the anti-SARC-CoV-2 properties of Schiff base metal complexes [16] , [17] , [18] , [19] . This present work describes the structure-based design, synthesis and anti-virus effect of two new coordination complexes, a Ni(II) complex [Ni(L) 2 ] ( 1 ) and a Cu(II) complex [Cu(L) 2 ] ( 2 ) of (E)-N-phenyl-2-(thiophen-2-ylmethylene) hydrazine-1-carbothioamide ( HL ) as antivirus drug candidates against SARS-CoV-2 and HIV virus.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and characterization of novel Ni(II) and Cu(II) complexes as antivirus drug candidates against SARS-CoV-2 and HIV virus

Aprajita

Choudhary

2022

Journal of Molecular Structure

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Experimental and computational study of naphthalimide derivatives: Synthesis, optical, nonlinear optical and antiviral properties

Cited by 13 publications

References 23 publications

Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates

Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates

Fluorescent Polymers for Environmental Monitoring: Targeting Pathogens and Metal Contaminants with Naphthalimide Derivatives

Design, synthesis and characterization of novel Ni(II) and Cu(II) complexes as antivirus drug candidates against SARS-CoV-2 and HIV virus

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