Within this contribution, the low-velocity impact behavior of sandwich structures was investigated. The sandwich structures consisted of carbon fiber reinforced polymer (CFRP) face sheets in various setups, and different core structures, including an open-cell and a closed-cell aluminum foam. The matrix of the face sheets was foamed polyurethane, which also acts as the adhesive connecting the face sheets to the core. Low-velocity indentation tests were carried out with multiple sandwich configurations. The indentation behavior was further examined by additional quasi-static indentation tests, and in situ indentation tests sequentially recorded by X-ray computed tomography. Both the low velocity indentation tests and the quasi-static tests were supported by digital image correlation measurements of the lower specimen surfaces. The overall indentation behavior was described consistently to sandwich structures with different material combinations in literature. The influence of each sandwich configuration parameter on the indentation behavior was determined and described in detail.