Experimental and Constitutive Approaches for a Study of Mechanical Properties of Animal Tendons

Liber-Kneć, Aneta; Łagan, Sylwia

doi:10.1007/978-3-030-29885-2_26

Cited by 6 publications

(7 citation statements)

References 14 publications

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“…At the same time, many studies assume that soft tissue is an incompressible hyperelastic and isotropic material, and use Ogden model, Yeoh model or other models to describe the stress-strain relationship of skin and tendon structure ( Cheng and Gan, 2008 ; Remache et al, 2018 ). Compared with previous studies, this study adopted a simplified Yeoh model, which was proved to be the most suitable for fitting hyperelastic and transversely isotropic tendons ( Liber-Kneć and Łagan, 2020 ). In the existing research, there are few studies on directly obtaining the mechanical data of tendon elastin before and after degradation and fitting the constitutive model at the same time.…”

Section: Discussionmentioning

confidence: 99%

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Liu,

Deng,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

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Background: The treatment of patellar tendon injury has always been an unsolved problem, and mechanical characterization is very important for its repair and reconstruction. Elastin is a contributor to mechanics, but it is not clear how it affects the elasticity, viscoelastic properties, and structure of patellar tendon.Methods: The patellar tendons from six fresh adult experimental pigs were used in this study and they were made into 77 samples. The patellar tendon was specifically degraded by elastase, and the regional mechanical response and structural changes were investigated by: (1) Based on the previous study of elastase treatment conditions, the biochemical quantification of collagen, glycosaminoglycan and total protein was carried out; (2) The patellar tendon was divided into the proximal, central, and distal regions, and then the axial tensile test and stress relaxation test were performed before and after phosphate-buffered saline (PBS) or elastase treatment; (3) The dynamic constitutive model was established by the obtained mechanical data; (4) The structural relationship between elastin and collagen fibers was analyzed by two-photon microscopy and histology.Results: There was no statistical difference in mechanics between patellar tendon regions. Compared with those before elastase treatment, the low tensile modulus decreased by 75%–80%, the high tensile modulus decreased by 38%–47%, and the transition strain was prolonged after treatment. For viscoelastic behavior, the stress relaxation increased, the initial slope increased by 55%, the saturation slope increased by 44%, and the transition time increased by 25% after enzyme treatment. Elastin degradation made the collagen fibers of patellar tendon become disordered and looser, and the fiber wavelength increased significantly.Conclusion: The results of this study show that elastin plays an important role in the mechanical properties and fiber structure stability of patellar tendon, which supplements the structure-function relationship information of patellar tendon. The established constitutive model is of great significance to the prediction, repair and replacement of patellar tendon injury. In addition, human patellar tendon has a higher elastin content, so the results of this study can provide supporting information on the natural properties of tendon elastin degradation and guide the development of artificial patellar tendon biomaterials.

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Section: Discussionmentioning

confidence: 99%

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Liu,

Deng,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

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“…Given the viscoelastic properties of tendons and their daily stress environment, we characterized the mechanical properties of the scaffold in vitro using quasi-static (0.5% s −1 , 3 mm min −1 ) [85][86][87][88] and dynamic (20% s −1 , 120 mm min −1 ) [62,89,90] strain rate (figure 2(c)), to simulate its response to daily service forces and sudden rupture forces respectively. P-BS served as a control.…”

Section: Preparation and Mechanical Characterization Of Fny-bsmentioning

confidence: 99%

“…To assess the quality of tendon regeneration, we tested the biomechanical properties of repaired tendons at 2 and 8 weeks postoperatively (figure 7(a)). The quasistatic strain rate (0.5% s −1 ) was adopted to evaluate the response of repaired tendons in daily activities [85][86][87][88]. In order to better analyze the mechanical behavior of the repaired tendon, we used the mechanical data of P-BS and FNY-BS before implantation as a control (with the same test parameters).…”

Section: Fny-bs Reconstructed the Biomechanical Mechanical Properties...mentioning

confidence: 99%

Micro–nano hierarchical scaffold providing temporal-matched biological constraints for tendon reconstruction

Xie,

Xu,

Lin

et al. 2023

Biofabrication

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Due to the limitations of tendon biology, high-quality tendon repair remains a clinical and scientific challenge. Here, a micro–nano hierarchical scaffold is developed to promote orderly tendon regeneration by providing temporal-matched biological constraints. In short, fibrin (Fb), which provides biological constraints, is loaded into poly (DL-lactide-co-glycolide) nanoyarns with suitable degradation cycles (Fb-loaded nanofiber yarns (Fb-NY)). Then further combined with braiding technology, temporary chemotactic Fb scaffolds with tendon extracellular matrix-like structures are obtained to initiate the regeneration process. At the early stage of healing (2 w), the regeneration microenvironment is regulated (inducing M2 macrophages and restoring the early blood supply necessary for healing) by Fb, and the alignment of cells and collagen is induced by nanoyarn. At the late healing stage (8 w), with the degradation of Fb-NY, non-functional vascular regression occurs, and the newborn tissues gradually undergo load-bearing remodeling, restoring the anvascularous and ordered structure of the tendon. In summary, the proposed repair strategy provides temporal-matched biological constraints, offering a potential pathway to reconstruct the ordered structure and function of tendons.

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“…The need for in silico mechanical models for simulating surgical procedures boosted the development of biological mechanical properties and the study of multiple biological materials, such as muscles [2][3][4][5], tendons [6], brain [7,8], skin [9,10], arteries and veins [11][12][13], and eye tissues [14,15]. In all cases, material properties are obtained from adjusting experimental data, where time dependence is evaluated by tests run at different strain rates [16].…”

Section: Introductionmentioning

confidence: 99%

Iterative Methods for the Biomechanical Evaluation of Corneal Response. A Case Study in the Measurement Phase

et al. 2021

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The number of corneal surgeries steadily grew in recent years and boosted the development of corneal biomechanical models. These models can contribute to simulating surgery by reducing associated risks and the need for secondary interventions due to ectasias or other problems related to correcting other diseases. Biomechanical models are based on the geometry obtained with corneal topography, which is affected by intraocular pressure and material properties. Knowledge of stress distribution in the measurement phase is a key factor for improving the accuracy of in silico mechanical models. In this work, the results obtained by two different methods: prestress method and displacements method were compared to evaluate the stress and strain distribution in a general geometric model based on the Navarro eye geometry and two real corneal geometries. The results show that both methods are equivalent for the achievement of the stress distribution in the measurement phase. Stress distribution over the corneal geometry in the measurement phase is a key factor for accurate biomechanical simulations, and these simulations could help to develop patient-specific models and reduce the number of secondary interventions in clinical practice.

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Experimental and Constitutive Approaches for a Study of Mechanical Properties of Animal Tendons

Cited by 6 publications

References 14 publications

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion

Micro–nano hierarchical scaffold providing temporal-matched biological constraints for tendon reconstruction

Iterative Methods for the Biomechanical Evaluation of Corneal Response. A Case Study in the Measurement Phase

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