Experimental and modeling investigation on the solubility of β-carotene in pure and ethanol-modified subcritical water

Mottahedin, Pouya; Asl, Ali Haghighi; Lotfollahi, Mohammad Nader

doi:10.1016/j.molliq.2017.04.036

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…32] illustrates the dielectric constant values for different temperatures and different volume percentages of ethanol in water.β-Carotene solubility data from this work and a previous work[30] can be correlated with the dielectric constant values in table 2.…”

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confidence: 54%

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Optimization of β-carotene solubility in pressurized hot water using a dynamic method and factorial methodology

Ebrahimi

Asl

Mottahedin

2019

BCC

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In this experimental investigation, the solubility of β-carotene in pressurized hot water was measured at temperatures in the range of (70-130) °C and the pressure of 20 bar by using a dynamic method. The influence of different variables, including temperature and flow rate in the range of (0.15-0.64) ml/min, on the solubility of β-carotene was investigated. Furthermore, the optimization of these parameters was done through the experimental design by using factorial methodology. The results of the experiments showed that the temperature was the main parameter affecting the solubility of β-carotene in pressurized hot water. The best conditions for solubility of β-carotene in pressurized hot water were the temperature of 85 °C and a flow rate of 0.64 ml/min. β-carotene’s solubility data in pressurized hot water were correlated with the dielectric constant values of the solvent mixture.

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confidence: 54%

“…Solubility measurements were conducted with a dynamic flow type system [30]. This apparatus is schematically shown in Fig.…”

Section: Apparatus and Methodsmentioning

confidence: 99%

Optimization of β-carotene solubility in pressurized hot water using a dynamic method and factorial methodology

Ebrahimi

Asl

Mottahedin

2019

BCC

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“…The temperature dependence of the drug solubility in a solvent can be modeled by empirical correlation [ 17 , 18 ], and by the activity coefficient method [ 19 , 20 ]. To select an appropriate model to describe the solubility of metoprolol succinate in the tested solvents, the experimental solubility data were correlated using three models: the modified Apelblat equation [ 21 ], the Wilson model [ 22 ], and the NRTL model [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents

Shen

Liang

2018

Molecules

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The solubilities of metoprolol succinate (a cardioselective β1 adrenergic receptor) in methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl acetate, and acetone were measured at temperatures ranging from (278.2 to 318.2) K using a solid–liquid equilibrium method. The solubility of metoprolol succinate increases with increasing temperature. At a fixed temperature, the solubility decreases in the order methanol > ethanol > n-butanol > n-propanol > isopropanol > acetone > ethyl acetate. The enthalpy of fusion and the melting point of metoprolol succinate were determined by differential scanning calorimetry. The thermodynamic properties of the dissolution process, determined by a van’t Hoff analysis, have been obtained and are discussed. The modified Apelblat equation, Wilson model, and non-random two-liquid (NRTL) model were employed to correlate the solubilities of metoprolol succinate in different solvents. Finally, a quantitative structure–property relationship (QSPR) study of physical properties of solvents and density functional theory simulations of hydrogen-bonding structure were carried out to give the explanation for the sequence of solubility in alcohols. The density functional theory (DFT) calculations well illustrated that the solubility of metoprolol succinate in various alcohols can be mainly attributed to the intra- and intermolecular hydrogen bonds in metoprolol succinate-solvent complexes.

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“…The solubility of β -carotene in subcritical water and ethanol-modified subcritical water mixture was investigated by Mottahedin et al [ 48 ] and Ebrahimi et al [ 49 ]. The response surface methodology was used to determine the optimal experimental conditions, and the independent variables were selected as temperature, subcritical water flow rate and % ( v / v ) of ethanol as co-solvent.…”

Section: Solubility In Subcritical Watermentioning

confidence: 99%

Solubility and Decomposition of Organic Compounds in Subcritical Water

et al. 2023

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In this article, studies on organic solubility and stability in subcritical water reported during the past 25 years have been reviewed. Data on the solubility and decomposition of organic compounds in subcritical water, a green solvent, are needed in environmental remediation, chemistry, chemical engineering, medicine, polymer, food, agriculture, and many other fields. For solubility studies, the experimental systems used to measure solubility, mathematical equations derived and applied for the modeling of the experimentally determined solubility data, and the correlation between the predicated and experimental data have been summarized and discussed. This paper also reviewed organic decomposition under subcritical water conditions. In general, the solubility of organics is significantly enhanced with increasing water temperature. Likewise, the percentage of organic decomposition also increases with higher temperature.

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Experimental and modeling investigation on the solubility of β-carotene in pure and ethanol-modified subcritical water

Cited by 11 publications

References 44 publications

Optimization of β-carotene solubility in pressurized hot water using a dynamic method and factorial methodology

Optimization of β-carotene solubility in pressurized hot water using a dynamic method and factorial methodology

Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents

Solubility and Decomposition of Organic Compounds in Subcritical Water

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