Bridges are the lifelines of disasters in earthquake areas. Therefore, it is very necessary to ensure the safety and traffic function after earthquake. Seismic isolation refers to install external energy dissipation devices or external energy input devices in specific parts of engineering structures. There are certain differences in longitudinal and transverse seismic responses of multi-span continuous beam bridges by changing the seismic dynamic characteristics or dynamic effects of structures. It is difficult to achieve the purpose of seismic isolation in both horizontal directions using isolation devices alone. The rubber deformation ability of lead rubber bearings can effectively insulate, and the yield energy consumption ability of its lead core can effectively consume the seismic energy for damping. The horizontal resistance is very small under the creep load, and the stiffness decreases rapidly after yielding under the strong dynamic earthquake load; meanwhile, the seismic energy is dissipated by the hysteresis of bearing. Fluid viscous damper is a velocity-dependent energy dissipation device, which produces viscous damping force, provides strong restoring force for components, and has a good limit function. This process will also dissipate the seismic energy, so as to reduce the structural earthquake response. Using these two methods together, the horizontal seismic responses of multi-span continuous beam bridges can be effectively controlled at the same time. Based on this idea, this article takes a high-speed multi-span continuous beam bridge with equal section as the engineering background, and uses dynamic time history analysis method to discuss the seismic isolation effect of lead rubber bearings and fluid viscous dampers.