The catalytic propane dehydrogenation (PDH) reaction was carried out in a bench-scale fluidized bed utilizing both experimental and computational methods. In order to investigate the reaction kinetics of CrO x -based catalysts, an Eulerian numerical model was utilized in conjunction with a modified energy-minimization multiscale (EMMS) drag model. On the basis of which, the effects of the catalyst packing temperature, the propane weight hourly space velocity (WHSV), and the PDH catalyst composition on propane conversion were evaluated. The results revealed that, when the catalyst packing temperature increased from 823 to 923 K, the conversion rose by 104.