Experimental and numerical responses of fibroblast and epithelial cells to the frequency of electric toothbrush

Heydarian, Ashkan; Darvishi, Parvin; Mortazavi, Hamed; Beni, Hamidreza Mortazavy

doi:10.1016/j.jmbbm.2023.105697

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The appropriate response analysis of biomedical materials, modeling of medical phenomena, description of flow in the arteries, or optimization of treatment techniques, together with imaging of biological tissues, internal organs, or blood vessels, are some examples of the current research topics under consideration [1][2][3][4][5][6]. Problems of a similar kind are often identified or determined by medics and doctors and investigated with the aid of medical testing devices or laboratory apparatus.…”

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of Mice Carotid Arteries’ Response Emphasizing the Importance of Material Law Constants’ Validation

Sobczyk,

Chróścielewski,

Wilde

2024

Applied Sciences

View full text Add to dashboard Cite

In this paper, a detailed validation of the passive material properties of mice carotid arteries and constants of the Fung and Holzapfel hyperelastic material laws is conducted by means of static nonlinear FEM analyses. The response of the carotid arteries in an inflation test is studied here for the following mouse models: wild-type, mdx, sgcd−/−, Eln+/+, Eln+/−, Fbln5+/+, and Fbln5−/−. All FEM computations are conducted on models that have been preliminarily checked for their reliability. The results of the calculations, namely, the relation between the internal pressure and the artery outer diameter, are verified against experimental responses and the applicability of the laws is assessed. New sets of Holzapfel constitutive relation constants are proposed for Eln+/+ and Fbln5−/− mice. Finally, the problem of carotid artery buckling is also discussed. The buckling pressures of the arteries are predicted using FEM models and nonlinear static analyses. These values are compared with the reference experimental results, which allow for further validation of the constitutive relations. The research emphasizes that computations and numerical methods enable an accurate description of bioengineering processes and behaviors but only if the models used are appropriately validated.

show abstract