The development of coal seam fissures and gas migration process caused by mining disturbance has an extremely important influence on gas control and roadway stability. In this study, the desorption, diffusion, and migration tests of adsorbed gas under the coupling effect of temperature and uniaxial compression were conducted on four coal samples from Zhangxiaolou mine, using the temperature and pressure coupling test system of deep coal rocks. The test confirms that the higher the temperature, the faster the desorption and emission of the adsorbed gases in the coal, and the larger the volume of the emitted gases. Meanwhile, it is found that the adsorbed gases in the coal samples of Zhangxiaolou mine are carbon dioxide and methane in the order of content. It is found that during the uniaxial compression process, several large negative values of the pressure of the emitted gas occur during the stable growth stage of the crack. This indicates that the crack expansion makes a new negative pressure space inside the coal sample, and the negative pressure values increase continuously during the unstable growth phase of the crack until the coal sample is destroyed. And after the axial pressure is removed, the escaped gas pressure shows a large positive value due to the rebound of the coal matrix and the continuous desorption of a large amount of adsorbed gas from the new crack location, which has a significant hysteresis with respect to the occurrence of the peak stress. Meanwhile, the SEM images of the coal samples before and after the test are analyzed to confirm the cause of the negative pressure generation.