Micro-wire-cut electrode discharge machining (EDM) is an emerging manufacturing process in the field of micro-manufacturing to fabricate the complex profiles of micro-components. It is a complex process involving various process parameters such as pulse on time, pulse off time, wire speed, wire tension and current. In addition to micro-fabrication, this process can also be extended in the field of tool design and developments such as dies, moulds, precision manufacturing, contour cutting, etc., where complex shapes need to be generated with high-grade dimensional accuracy and surface finish. In this research work, an attempt is made to investigate the effect of process parameters on the output variables such as material removal rate (MRR), surface finish and the cutting width (kerf) of wire-cut EDM for duplex stainless steel (DSS). Scanning electron microscopy (SEM) has been used to capture the images of the kerf width, and the measurements are taken with the help of the welding expert system and software. An optimization technique (Taguchi method) has been employed to identify the optimum parameters of the micro-wire-cut EDM process for cutting 2205 grade duplex stainless steel. The effect of each control parameter on the performance measure is studied individually using the plots of signal to noise ratio.