Experimental and numerical study on the performance of printed alginate/hyaluronic acid/halloysite nanotube/polyvinylidene fluoride bio-scaffolds

Zineh, Babak Roushangar; Shabgard, Mohammad Reza; Roshangar, Leila; Jahani, Kamal

doi:10.1016/j.jbiomech.2020.109764

Cited by 11 publications

(11 citation statements)

References 52 publications

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“…Among these research studies, only seven papers focused on alginate hydrogel-based inks that contained clay; six of them referred to 3D composite constructs envisaged for tissue engineering. Thus, alginate was studied in combination with methylcellulose [ 17 , 26 ], PEGDA/gelatin [ 37 ], methylcellulose/polyvinylidene fluoride [ 38 ] or hyaluronic acid/polyvinylidene fluoride [ 39 ]. Four studies used disc-shaped, synthetic clay-Laponite [ 17 , 25 , 26 , 39 ], while two studies used halloysite nanotubes as the inorganic components embedded in the printing formulations [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, alginate was studied in combination with methylcellulose [ 17 , 26 ], PEGDA/gelatin [ 37 ], methylcellulose/polyvinylidene fluoride [ 38 ] or hyaluronic acid/polyvinylidene fluoride [ 39 ]. Four studies used disc-shaped, synthetic clay-Laponite [ 17 , 25 , 26 , 39 ], while two studies used halloysite nanotubes as the inorganic components embedded in the printing formulations [ 38 , 39 ]. Only one study used natural clay, namely, Cloisite 20A, but the 3D-printed constructs were not used for developing scaffolds for tissue engineering but for removing heavy metal ions from wastewaters [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

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3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

Alexa

Ianchiş

Savu

et al. 2021

Gels

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Biocompatibility, biodegradability, shear tinning behavior, quick gelation and an easy crosslinking process makes alginate one of the most studied polysaccharides in the field of regenerative medicine. The main purpose of this study was to obtain tissue-like materials suitable for use in bone regeneration. In this respect, alginate and several types of clay were investigated as components of 3D-printing, nanocomposite inks. Using the extrusion-based nozzle, the nanocomposites inks were printed to obtain 3D multilayered scaffolds. To observe the behavior induced by each type of clay on alginate-based inks, rheology studies were performed on composite inks. The structure of the nanocomposites samples was examined using Fourier Transform Infrared Spectrometry and X-ray Diffraction (XRD), while the morphology of the 3D-printed scaffolds was evaluated using Electron Microscopy (SEM, TEM) and Micro-Computed Tomography (Micro-CT). The swelling and dissolvability of each composite scaffold in phosfate buffer solution were followed as function of time. Biological studies indicated that the cells grew in the presence of the alginate sample containing unmodified clay, and were able to proliferate and generate calcium deposits in MG-63 cells in the absence of specific signaling molecules. This study provides novel information on potential manufacturing methods for obtaining nanocomposite hydrogels suitable for 3D printing processes, as well as valuable information on the clay type selection for enabling accurate 3D-printed constructs. Moreover, this study constitutes the first comprehensive report related to the screening of several natural clays for the additive manufacturing of 3D constructs designed for bone reconstruction therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

Alexa

Ianchiş

Savu

et al. 2021

Gels

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“…Within the last 5 years, several articles have been published that show that it is still of interest within scientific groups to research the blends of hyaluronic acid with other biopolymers [85,[94][95][96][97][98][99][100][101][102]. For example, new materials were prepared based on the mixtures of hyaluronic acid and carboxymethyl cellulose [94].…”

Section: Possible Application Of New Materials Based On the Blends Of Hyaluronic Acid With Other Natural Polymersmentioning

confidence: 99%

“…Ternary blends of silk fibroin, hyaluronic acid, and heparin were also studied for potential soft-tissue engineering [99]. A novel biomaterial made of alginate, hyaluronic acid, halloysite nanotube, and polyvinylidene fluoride has been proposed for printing cartilage scaffolds [100]. The hydrogel composed of hyaluronic acid and alginate as a potential bio-ink for 3D bioprinting of articular cartilage engineering constructs has been also proposed [101].…”

Section: Possible Application Of New Materials Based On the Blends Of Hyaluronic Acid With Other Natural Polymersmentioning

confidence: 99%

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

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“…[ 25–30 ] More importantly, it is urged to pursue new 3D printing materials to promote the development of bio‐scaffolds in the tissue engineering field with sustainable and environmentally friendly substance. [ 31–36 ] In addition to the diversity of IL monomer itself, it also has the characteristics of cross‐linking with different compounds, thus enriching the types and function of PILs. [ 37 ] PILs have been used to prepare antibacterial membrane, but only few studies used PILs for preparation of bio‐scaffolds.…”

Section: Introductionmentioning

confidence: 99%

3D Printing for Biological Scaffolds using Poly(Ionic Liquid)/Gelatin/Sodium Alginate Ink

Zhang

Wang

et al. 2021

Macro Materials & Eng

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The poly(ionic liquid)s (PILs) have attracted a wide range of applications in thermo‐responsive materials, carbon materials, catalysis, porous polymers, separation and absorption materials, and biological field due to their favorable tunability and biological functions. However, the applications of PILs in bio‐scaffold are rarely studied. In the present work, the ionic liquid (IL) monomer (1‐vinyl‐3‐butylimidazolium chloride, [VBIM]Cl) is cross‐linked with other three compounds, respectively, to synthesize three kinds of PILs (PIL1, PIL2, and PIL3). Furthermore, individually cross‐linked PILs are added into gelatin (Gel)/sodium alginate (SA) solution aiming to prepare biological inks (bio‐inks) for 3D printing. The water absorption, degradation rate, and porosity of the bio‐scaffolds are measured to evaluate the physicochemical characteristics, while the PC12 cell line is used to evaluate the biocompatibility of the bio‐scaffolds through cell proliferation. These results demonstrate that the biological activity of the bio‐scaffold can be varied at the tendency of PIL1 < PIL3 < PIL2, providing a potential prospect for the application of PILs in tissue‐engineered bio‐scaffolds.

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Experimental and numerical study on the performance of printed alginate/hyaluronic acid/halloysite nanotube/polyvinylidene fluoride bio-scaffolds

Cited by 11 publications

References 52 publications

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

3D Printing for Biological Scaffolds using Poly(Ionic Liquid)/Gelatin/Sodium Alginate Ink

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