Understanding the fluid flow mechanisms in fractured porous media plays an important role in many engineering activities, such as nuclear waste disposal, geothermal energy extraction, oil and natural gas production, as well as performance and safety of underground projects including coal mines and tunnels. In recent years, many methods including numerical simulation, laboratory experiment and theoretical analysis have been employed to investigate the flowing process and permeability response of rock mass and rock fractures, from kilometer scale to microscale. However, the rocks/coals are in deep underground that is very complex and exists some uncertainties. Therefore, new numerical simulation methods and deep explanations of fluid flow behaviors in fractured porous media are still needed [1-3]. Thus, the guest editors organized a special issue on "Modeling and Simulation of Fluid flows in Fractured Porous Media: Current Trends and Prospects" within Computer Modeling in Engineering & Sciences. This special issue aims at presenting recent advances and challenges in studies on the 3D fracture network reconstruction, fluid flow modeling and permeability estimation of rock fractures, with the potential topics including intelligent and secure face recognition system in smart cities, reconstruction of 3D rock fractures and permeability estimation, fluid flow and solute transport in fractured porous media, flow regime transition modeling in complicated fracture networks, usages of 3D printing, micro-CT scanning and scanning electron microscope (SEM) techniques, fracture shear behavior and shearflow process, effects of thermal treatment on dynamic and physical properties of rocks, and stability control modeling of underground surrounding rocks.