Thermodynamic, dynamic and design parameters have a significant and often conflicting impact on the transient response of a compression ignition engine. Knowing the contribution of each parameter on transient operation could direct the designer to the appropriate measures for better engine performance. To this aim an explicit simulation program developed is used to study the performance of a turbocharged diesel engine operating under transient load conditions. The simulation developed, based on the filling and emptying approach, provides various innovations as follows: Detailed analysis of thermodynamic and dynamic differential equations, on a degree crank angle basis, accounting for the continuously changing nature of transient operation, analysis of transient mechanical friction, and also a detailed mathematical simulation of the fuel pump. Each equation in the model is solved separately for every cylinder of the 6-cylinder diesel engine considered. The model is validated against experimental data for various load changes.The effect of several dynamic, thermodynamic and design parameters is studied, i.e. load schedule (type, and duration of load applied), turbocharger mass moment of inertia, exhaust manifold volume and configuration, cylinder wall temperature, aftercooler effectiveness as well as an interesting case of a malfunctioning fuel pump.Explicit diagrams are given to show how, after an increase in load, each parameter examined affects the engine speed response, as well as other properties of the engine and turbocharger such as fuel pump rack position, boost pressure and turbocharger speed.It is shown that certain parameters, such as the type of connected loading, the turbocharger inertia, a damaged fuel pump and the exhaust manifold volume, can have a significant effect on the engine and turbocharger transient performance. However others, such as the cylinder wall temperature, the aftercooler effectiveness and the exhaust manifold configuration have a less important effect as regards transient response and final equilibrium conditions.