Experimental and simulation studies of localization and decoding of single and double dipoles

Zhang, Hao; Xu, Minpeng; Zhang, Chen; He, Feng; Song, Xizi; Chen, Shanguang; Jian, Xiqi; Ming, Dong

doi:10.1088/1741-2552/ac6a12

Cited by 7 publications

(7 citation statements)

References 28 publications

(32 reference statements)

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“…In 2021, Song et al conducted a steadystate visual evoked potentials (SSVEPs) experiment in living rats based on ABI, and the experimental results showed that the decoded AE signal had high amplitude responses at both fundamental and harmonic of the visual stimulus frequency, and this experimental study realized the first millimeter spatial resolution SSVEP measurement in living rats [9]. In 2022 Zhang et al used FUS irradiation to simulate the dipole of neuronal discharge, and the simulation and experimental results showed that the localization and decoding results were highly consistent with the preset parameters, and the dipole localization error was less than 0.3 mm [10].…”

Section: Introductionmentioning

confidence: 52%

“…Each electrode was inserted into the y = 0 section in the phantom along the y-axis direction according to the set position, where the phantom is composed of acrylamide (AM), ammonium persulfate (APS), N, N ′ -methylenebisacrylamide (MBA), and N, N, N ′ , N ′ -tetramethylethylenediamine (TEMED), egg white solution, and physiological saline [10,28]. For the single-source experiments in Dipole1+, the transducer was modulated to perform a 2 mm × 2 mm raster scan of the y = 0 cross-section in 0.2 mm steps using the array modulation method in 2.1.2 at an initial excitation voltage of 5 V for each array (purple area in figure 3(e)).…”

Section: Abi Experimental Methodsmentioning

confidence: 99%

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Transcranial dipole localization and decoding study based on ultrasonic phased array for acoustoelectric brain imaging

Zhang,

Wang

et al. 2023

J. Neural Eng.

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Objective. Neuroimaging is one of the effective tools to understand the functional activities of the brain, but traditional non-invasive neuroimaging techniques are difficult to combine both high temporal and spatial resolution to satisfy clinical needs. Acoustoelectric brain imaging (ABI) can combine the millimeter spatial resolution advantage of focused ultrasound with the millisecond temporal resolution advantage of electroencephalogram signals. Approach. In this study, we first explored the transcranial modulated acoustic field distribution based on ABI, and further localized and decoded single and double dipoles signals. Main results. The results show that the simulation-guided acoustic field modulation results are significantly better than those of self-focusing, which can realize precise modulation focusing of intracranial target focusing. The single dipole transcranial localization error is less than 0.4 mm and the decoding accuracy is greater than 0.93. The double dipoles transcranial localization error is less than 0.2 mm and the decoding accuracy is greater than 0.89. Significance. This study enables precise focusing of transcranial acoustic field modulation, high-precision localization of source signals and decoding of their waveforms, which provides a technical method for ABI in localizing evoked excitatory neuron areas and epileptic focus.

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Section: Introductionmentioning

confidence: 52%

Section: Abi Experimental Methodsmentioning

confidence: 99%

Transcranial dipole localization and decoding study based on ultrasonic phased array for acoustoelectric brain imaging

Zhang,

Wang

et al. 2023

J. Neural Eng.

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“…Barragan used a head phantom with a real human skull to demonstrate 4D ABI for mapping time-varying monopoles and dipoles at depths >60 mm with detection thresholds <0.5 mA ( Figure 4 ) (Barragan et al, 2020 ). In 2022, Zhang used FUS irradiation to simulate the dipole of neuronal firing, and the simulation and experimental results showed that the localization and decoding results were highly consistent with the predicted situation (Zhang et al, 2022 )).…”

Section: Research Progressmentioning

confidence: 70%

Biological current source imaging method based on acoustoelectric effect: A systematic review

Zhang

Liu

et al. 2022

Front. Neurosci.

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Neuroimaging can help reveal the spatial and temporal diversity of neural activity, which is of utmost importance for understanding the brain. However, conventional non-invasive neuroimaging methods do not have the advantage of high temporal and spatial resolution, which greatly hinders clinical and basic research. The acoustoelectric (AE) effect is a fundamental physical phenomenon based on the change of dielectric conductivity that has recently received much attention in the field of biomedical imaging. Based on the AE effect, a new imaging method for the biological current source has been proposed, combining the advantages of high temporal resolution of electrical measurements and high spatial resolution of focused ultrasound. This paper first describes the mechanism of the AE effect and the principle of the current source imaging method based on the AE effect. The second part summarizes the research progress of this current source imaging method in brain neurons, guided brain therapy, and heart. Finally, we discuss the problems and future directions of this biological current source imaging method. This review explores the relevant research literature and provides an informative reference for this potential non-invasive neuroimaging method.

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“…It has been demonstrated that AEBI can map DBS currents inside human skulls submerged in 0.9% NaCl solution [24][25]. Besides, we have demonstrated that the pulse repetition frequency (PRF) of FUS is capable of encoding electroencephalography (EEG) signal and decoding AE signal and proved its feasibility through in vivo rat brain AEBI experiments [26][27][28][29][30][31]. Furtherly, based on PRF, living rat steady-state visual evoked potentials activation was mapped and the AE signal processing network of the rat brain was revealed [32][33][34][35].…”

Section: Introductionmentioning

confidence: 80%

“…In this study, PRF was used to extract AE signal from raw signal which was validated in previous work [26][27][28][29][30][31]. The voltage signals acquired at each focal spot initially were used as the raw data and was first down sampled at 5000 Hz.…”

Section: Image Protocolmentioning

confidence: 99%

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Deep Brain Stimulation Currents

Zhou,

Song,

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Objective. Deep brain stimulation (DBS) is an effective treatment for neurologic disease and its clinical effect is highly dependent on the DBS leads localization and current stimulating state. However, standard human brain imaging modalities could not provide direct feedback on DBS currents spatial distribution and dynamic changes. Acoustoelectric brain imaging (AEBI) is an emerging neuroimaging method that can directly map current density distribution. Here, we investigate in vivo AEBI of different DBS currents to explore the potential of DBS visualization using AEBI. Method. According to the typical DBS stimulus parameters, four types of DBS currents, including time pattern, waveform, frequency, and amplitude are designed to implement AEBI experiments in living rat brains. Based on acoustoelectric (AE) signals, the AEBI images of each type DBS current are explored and the resolution is quantitatively analyzed for performance evaluation. Furtherly, the AE signals are decoded to characterize DBS currents from multiple perspectives, including time-frequency domain, spatial distribution, and amplitude comparation. Results. The results show that in vivo transcranial AEBI can accurately locate the DBS contact position with a millimeter spatial resolution (<2 mm) and millisecond temporal resolution (<10 ms). Besides, the decoded AE signal at DBS contact position is capable of describing the corresponding DBS current characteristics and identifying current pattern changes. Conclusion. This study first validates that AEBI can localize in vivo DBS contact and characterize different DBS currents. Significance. AEBI is expected to develop into a noninvasive DBS real-time monitoring technology with high spatiotemporal resolution.

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Experimental and simulation studies of localization and decoding of single and double dipoles

Cited by 7 publications

References 28 publications

Transcranial dipole localization and decoding study based on ultrasonic phased array for acoustoelectric brain imaging

Transcranial dipole localization and decoding study based on ultrasonic phased array for acoustoelectric brain imaging

Biological current source imaging method based on acoustoelectric effect: A systematic review

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Deep Brain Stimulation Currents

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