Experimental and statistical analysis of surface charge, aggregation and adsorption behaviors of surface-functionalized titanium dioxide nanoparticles in aquatic system

Xiang, Chengcheng; Yang, Feng; Li, Ming; Jaridi, Majid; Wu, Nianqiang

doi:10.1007/s11051-012-1293-7

Cited by 22 publications

(11 citation statements)

References 38 publications

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“…Instead we observed some level of aggregation even when conducted in DI water. According to classical Derjaguin-Landau-Verwey-Overbeak (DLVO) theory, within a stable zeta potential range of −30 to 30mV, increasing the surface charge or absolute value of zeta potential typically suppresses aggregation, thereby decreasing the NP hydrodynamic size [99, 101]. In fact, charging NPs has been used as a strategy to reduce aggregation [102, 103].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, charging NPs has been used as a strategy to reduce aggregation [102, 103]. However, expanded theories and experimental validation have suggested that surface-modification of NPs with cationic molecules can induce aggregation that may be further dependent on size, sterics, (bio)macromolecule modification, surface properties, hydrogen bonding, “back binding”, and other equivalent forces acting in parallel to van der Waal and electrical double layer (EDL) forces [100, 101, 104]. …”

Section: Discussionmentioning

confidence: 99%

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Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

2016

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The surface modification of nanoparticles (NPs) can enhance the intracellular delivery of drugs, proteins, and genetic agents. Here we studied the effect of different surface ligands, including cell penetrating peptides (CPPs), on the cell binding and internalization of poly(lactic-co-glycolic) (PLGA) NPs. Relative to unmodified NPs, we observed that surface-modified NPs greatly enhanced cell internalization. Using one CPP, MPG (unabbreviated notation), that achieved the highest degree of internalization at both low and high surface modification densities, we evaluated the effect of two different NP surface chemistries on cell internalization. After 2 hr, avidin-MPG NPs enhanced cellular internalization by 5 to 26-fold relative to DSPE-MPG NP formulations. Yet, despite a 5-fold increase in MPG density on DSPE- relative to Avidin-NPs, after 24 hr., both formulations resulted in similar internalization levels (48 and 64-fold, respectively). Regardless of surface modification, all NPs were internalized through an energy-dependent, clathrin-mediated process, and became dispersed throughout the cell. Overall both Avidin- and DSPE-CPP modified NPs significantly increased internalization and offer promising delivery options for applications in which internalization presents challenges to efficacious delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

2016

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“…The NPs have active surfaces and can interact with molecules, organic material, biocolloids, and clays [13][14][15]. Consequently, NPs that enter the environment undergo surface interactions, producing very stable agglomerates, which are capable of migrating over long distances [16][17][18][19][20][21][22][23][24]. The toxicological risks that NPs can pose to human health and the environment have not been thoroughly examined yet [25].…”

Section: Introductionmentioning

confidence: 99%

“…The stability of TiO 2 NPs in aqueous solutions is significantly affected by solution pH, surface charge, inorganic salts, and organic matter [13,21,23,24]. Also, the initial NP concentration plays an important role in agglomerate growth, especially for concentrations ranging between 0.1 and 10 mg/L [21].…”

Section: Introductionmentioning

confidence: 99%

Characterization of TiO2 nanoparticle suspensions in aqueous solutions and TiO2 nanoparticle retention in water-saturated columns packed with glass beads

Sygouni

Chrysikopoulos

2015

Chemical Engineering Journal

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“…Mostly, the physicochemical properties, including the shape, 9 size 10 and surface chemistry, 11 decide the fate of the INM. Mostly, the physicochemical properties, including the shape, 9 size 10 and surface chemistry, 11 decide the fate of the INM.…”

Section: Zhaomentioning

confidence: 99%

Biomedical applications of nano-titania in theranostics and photodynamic therapy

et al. 2016

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Titanium dioxide (TiO2) is one of the most abundantly used nanomaterials for human life. It is used in sunscreen, photovoltaic devices, biomedical applications and as a food additive and environmental scavenger. Nano-TiO2 in biomedical applications is well documented. It is used in endoprosthetic implants and early theranostics of neoplastic and non-neoplastic maladies as a photodynamic therapeutic agent and as vehicles in nano-drug delivery systems. Herein, we focus on the recent advancements and applications of nano-TiO2 in bio-nanotechnology, nanomedicine and photodynamic therapy (PDT).

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Experimental and statistical analysis of surface charge, aggregation and adsorption behaviors of surface-functionalized titanium dioxide nanoparticles in aquatic system

Cited by 22 publications

References 38 publications

Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

Characterization of TiO2 nanoparticle suspensions in aqueous solutions and TiO2 nanoparticle retention in water-saturated columns packed with glass beads

Biomedical applications of nano-titania in theranostics and photodynamic therapy

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