Experimental and theoretical studies of the rhodium(i)-catalysed C–H oxidative alkenylation/cyclization ofN-(2-(methylthio)phenyl)benzamides with maleimides

Abstract

The rhodium(I)-catalysed reaction of aromatic amides that contain a 2-(methylthio)aniline directing group with maleimides gives isoindolone spirosuccinimides as products under aerobic, metal oxidant-free, and solvent-free conditions. In sharp contrast to...

Recent advances in spirocyclization of maleimides via transition-metal catalyzed C–H activation

“…Very recently in 2023, Skhiri and co-workers reported the N -aryl linked secondary amide derived spirocycles 63 , from the Rh-catalyzed reaction of N -aryl benzamides 62 and maleimides in the presence of PivOH under solvent-free conditions and under air at 160 °C (Scheme 13). 18 Various substitutions on the phenyl ring have been tested for the sake of generalizing the reaction and pleasingly up to 99% yields of the products have been isolated. But in the case of 63a , a low yield of the product (27%) was observed.…”