2017
DOI: 10.1016/j.tet.2017.01.047
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Experimental and theoretical study on the regioselective bis- and polyalkylation of 2-mercaptonicotinonitrile and 2-mercaptopyrimidine-5-carbonitrile derivatives

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Cited by 42 publications
(18 citation statements)
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“…In connection with these findings and in continuation of our recent interest in the chemistry of bis‐ and poly(heterocycles), we report herein on the synthesis of novel bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles). The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF‐7), liver cancer cell line (HepG‐2), and epithelial colorectal adenocarcinoma cells (CaCO‐2).…”
Section: Introductionmentioning
confidence: 71%
“…In connection with these findings and in continuation of our recent interest in the chemistry of bis‐ and poly(heterocycles), we report herein on the synthesis of novel bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles). The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF‐7), liver cancer cell line (HepG‐2), and epithelial colorectal adenocarcinoma cells (CaCO‐2).…”
Section: Introductionmentioning
confidence: 71%
“…In the last decades, our group has been heavily involved in a program aiming at exploring the synthetic potentiality of functionally substituted enamines . In continuation to this work, and in conjunction to our interest in the chemistry of bis(heterocycles) , we report herein on the reactivity patterns of enamines towards 1 H ‐1,2,4‐triazol‐5‐amine and 6‐amino‐2‐thioxopyrimidin‐4‐one.…”
Section: Introductionmentioning
confidence: 96%
“…In view of the aforementioned facts and as part of our research interest in both bis‐heterocycles and the Michael addition reaction using substituted cinnamonitrile derivatives , we report herein the results of our investigations concerning the reactivity pattern of 3‐amino‐5‐(cyanomethyl)‐1 H ‐pyrazole‐4‐carbonitrile 4 towards bis‐cinnamonitrile derivatives 3 .…”
Section: Introductionmentioning
confidence: 98%