Experimental Animal Models for Meniere’s Disease: A Mini-Review

Seo, Young Joon; Brown, Daniel

doi:10.7874/jao.2020.00115

Cited by 14 publications

(6 citation statements)

References 45 publications

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“…Current existing animal models can resemble the dilation of SM and low-frequency hearing loss. It is widely accepted that the EH animal models, created through surgical operation, medication application, or their combination, can reproduce the chronic phase of MD ( Seo and Brown, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

Wang

et al. 2022

Front. Cell. Neurosci.

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BackgroundEndolymphatic hydrops (EH) is considered as the pathological correlate of Menière’s disease (MD) and cause of hearing loss. The mechanism of EH, remaining unrevealed, poses challenges for formalized clinical trials.ObjectiveThis study aims to investigate the development of hearing loss, as well as the effect of dehydration treatment on EH animal models.MethodsIn this study, different severity EH animal models were created. The laser Doppler vibrometer (LDV) and auditory brainstem responses (ABR) were used to study the effects of EH and the dehydration effects of mannitol. The LDV was used to measure the vibration of the round window membrane (RWM) reflecting the changes in inner ear impedance. ABR was used to evaluate the hearing changes. Furthermore, tissue section and scanning electron microscopy (SEM) observations were used to analyze the anatomical change to the cochlea and outer hair cells.ResultsThe RWM vibrations decreased with the severity of EH, indicating an increase in the cochlear impedance. The dehydration therapy lowered the impedance to restore acoustic transduction in EH 10- and 20-day animal models. Simultaneously, the ABR thresholds increased in EH models and were restored after dehydration. Moreover, a difference in the hearing was found between ABR and LDV results in severe EH animal models, and the dehydration therapy was less effective, indicating a sensorineural hearing loss (SNHL).ConclusionEndolymphatic hydrops causes hearing loss by increasing the cochlear impedance in all tested groups, and mannitol dehydration is an effective therapy to restore hearing. However, SNHL occurs for the EH 30-day animal models, limiting the effectiveness of dehydration. Our results suggest the use of dehydrating agents in the early stage of EH.

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Section: Discussionmentioning

confidence: 99%

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

Wang

et al. 2022

Front. Cell. Neurosci.

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“…In Meniere's disease, histopathological temporal bone studies have shown that circulatory disturbances might cause abnormal endolymph homeostasis. [51,52]. A greater volume of the endolymphatic fluid causes the cochlear lateral wall, including the capillary network, to be compressed against the bony labyrinth, and ischemic reperfusion damage can be caused by this increase in cochlear outflow resistance.…”

Section: Discussionmentioning

confidence: 99%

The Risk of BPPV, Meniere’s Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

Choi

Kim

Chung

2022

JCM

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This study evaluated the impact of pre-existing gout on the occurrence of benign paroxysmal positional vertigo (BPPV), Meniere’s disease, and vestibular neuronitis, with the goal of identifying novel associations of gout with other comorbid diseases. The 2002–2019 Korean National Health Insurance Service Health Screening Cohort data were retrospectively analyzed. 23,827 patients with gout were matched to 95,268 controls without gout for age, sex, income, region of residence, and index date. The occurrence of BPPV, Meniere’s disease, and vestibular neuronitis was evaluated in both groups. The hazard ratios (HRs) of gout for BPPV, Meniere’s disease, and vestibular neuronitis were calculated using a stratified Cox proportional hazard model. Participants with gout demonstrated a 1.13-fold higher risk of BPPV (95% CI, 1.06–1.21, p < 0.001) and a 1.15-fold higher risk of Meniere’s disease (95% CI, 1.15–1.37, p < 0.001) than the matched control group. However, the HR for vestibular neuronitis was not significantly higher in the gout group (adjusted HR = 1.06, 95% CI, 0.93–1.21, p = 0.391). A previous history of gout was related to a higher risk of BPPV and Meniere’s disease. Additional studies are necessary to elucidate the mechanism underlying the relationship between gout and comorbid diseases such as BPPV and Meniere’s disease.

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“…Similarly, the administration of vasopressin acts on the V2-aquaporin 2 receptor couple present in the endolymphatic sac to generate hydrops. Although these models do not always induce auditory or vestibular deficits in animals, they nevertheless allow confirmation that local administrations of compounds likely to act on the osmolarity of the endolymph, such as diuretics, are capable of significantly reducing hydrops [ 34 , 35 , 36 ]. The degree of predictivity of these study models must however be balanced by the fact that the etiology of Menière disease is certainly multiple, and that hydrops is perhaps a histological correlate which is not mandatory to the expression of the vestibular syndrome.…”

Section: Animal Models Of Peripheral Vestibulopathiesmentioning

confidence: 99%

What Predictability for Animal Models of Peripheral Vestibular Disorders?

et al. 2022

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The different clinical entities grouped under the term peripheral vestibulopathies (PVs) or peripheral vestibular disorders (PVDs) are distinguished mainly based on their symptoms/clinical expression. Today, there are very few commonly accepted functional and biological biomarkers that can confirm or refute whether a vestibular disorder belongs to a precise classification. Consequently, there is currently a severe lack of reliable and commonly accepted clinical endpoints, either to precisely follow the course of the vertigo syndrome of vestibular origin or to assess the benefits of therapeutic approaches, whether they are pharmacological or re-educational. Animal models of PV are a good means to identify biomarkers that could subsequently be exploited in human clinical practice. The question of their predictability is therefore crucial. Ten years ago, we had already raised this question. We revisit this concept today in order to take into account the animal models of peripheral vestibular pathology that have emerged over the last decade, and the new technological approaches available for the behavioral assessment of vestibular syndrome in animals and its progression over time. The questions we address in this review are the following: are animal models of PV predictive of the different types and stages of vestibular pathologies, and if so, to what extent? Are the benefits of the pharmacological or reeducational therapeutic approaches achieved on these different models of PV (in particular the effects of attenuation of the acute vertigo, or acceleration of central compensation) predictive of those expected in the vertiginous patient, and if so, to what extent?

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Experimental Animal Models for Meniere’s Disease: A Mini-Review

Cited by 14 publications

References 45 publications

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs

The Risk of BPPV, Meniere’s Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

What Predictability for Animal Models of Peripheral Vestibular Disorders?

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