Experimental application of boron neutron capture therapy to undifferentiated thyroid carcinoma

Dagrosa, María Alejandra; Viaggi, M.; Longhino, Juan; Calzetta, Osvaldo; Cabrini, R. L.; Edreira, Martín M.; Juvenal, Guillermo; Pisarev, Mario A.

doi:10.1016/s0360-3016(03)00778-8

Cited by 23 publications

(13 citation statements)

References 15 publications

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“…The animal model used was based in Balb/c nu/nu, a strain of athymic mice, where xenotransplants were obtained by injection of 4 × 10 6 cells (A375 or WiDR) in the dorsal region. Tumours were monitored in order to check its volume according to the following expression: V = (L × S 2 )/2, where L is the largest axis of the tumour and the smallest axis is S [23,24]. When tumour volume reached 300-500 mm 3 , the sensitizers (2 mg/kg) were administered intraperitoneally.…”

Section: In Vivo Studiesmentioning

confidence: 99%

2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies

Laranjo

Serra

Abrantes

et al. 2013

Photodiagnosis and Photodynamic Therapy

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Section: In Vivo Studiesmentioning

confidence: 99%

2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies

Laranjo

Serra

Abrantes

et al. 2013

Photodiagnosis and Photodynamic Therapy

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“…When tumor volume reached 300-500 mm 3 , an aqueous solution of AA with a concentration of 150 mg/kg was daily injected intraperitoneally during 12 days. Tumor volume was estimated according to Dagrosa et al (29). After therapy, the mice were killed by cervical dislocation.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

Mamede

Pires

Abrantes

et al. 2012

Nutrition and Cancer

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Vitamin C, available in its reduced form (ascorbic acid; AA) and in its oxidized form (dehydroascorbic acid; DHA), may act in physiological conditions as an antioxidant or pro-oxidant. The aim of this study is to evaluate the cytotoxic effects of pharmacological doses of AA in a human colorectal adenocarcinoma cell line (WiDr) in vitro, through spectrophotometry, clonogenic assays and flow cytometry, and in vivo with xenotransplanted Balb/c nu/nu mice. The results show that the reduced form of vitamin C induces an anti-proliferative and cytotoxic effect in adenocarcinoma colorectal cells under study. The results obtained in vivo after treatment with AA showed a large reduction in the rate of tumor growth. Such understanding can guide decisions about which colorectal cancer patients might potentially benefit from vitamin C pharmacologic therapy.

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“…Despite these constraints, clear evidence of therapeutic efficacy with no signs of radiotoxicity is presented. In this context, the present study contributes data on a clinically relevant and thus inevitably complex model that allows for cautious extrapolation to a clinical scenario beyond some of the usual end points reported in BNCT studies in implanted tumor models such as an increase in survival time of a few days (38) and a decrease in tumor growth (39).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Success of Boron Neutron Capture Therapy (BNCT) Mediated by a Chemically Non-selective Boron Agent in an Experimental Model of Oral Cancer: A New Paradigm in BNCT Radiobiology

et al. 2006

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The hypothesis of boron neutron capture therapy (BNCT) research has been that the short-range, high-linear energy transfer radiation produced by the capture of thermal neutrons by (10)B will potentially control tumor and spare normal tissue only if the boron compound selectively targets tumor tissue within the treatment volume. In a previous in vivo study of low-dose BNCT mediated by GB-10 (Na(2)(10)B(10)H(10)) alone or combined with boronophenylalanine (BPA) in the hamster cheek pouch oral cancer model that was primarily designed to evaluate safety and feasibility, we showed therapeutic effects but no associated normal tissue radiotoxicity. In the present study, we evaluated the response of tumor, precancerous and normal tissue to high-dose BNCT mediated by GB-10 alone or combined with BPA. Despite the fact that GB-10 does not target hamster cheek pouch tumors selectively, GB-10-BNCT induced a 70% overall tumor response with no damage to normal tissue. (GB-10+BPA)-BNCT induced a 93% overall tumor response with no normal tissue radiotoxicity. Light microscope analysis showed that GB-10-BNCT selectively damages tumor blood vessels, sparing precancerous and normal tissue vessels. In this case, selective tumor lethality would thus result from selective blood vessel damage rather than from selective uptake of the boron compound.

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Experimental application of boron neutron capture therapy to undifferentiated thyroid carcinoma

Cited by 23 publications

References 15 publications

2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies

2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies

Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

Therapeutic Success of Boron Neutron Capture Therapy (BNCT) Mediated by a Chemically Non-selective Boron Agent in an Experimental Model of Oral Cancer: A New Paradigm in BNCT Radiobiology

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