Experimental Application of Tissue Adhesives in Corneal Traumas

Papadopoulou, Domniki N.; Sionga, Antonia; Karayannopoulou, Georgia; Natsis, Konstantinos; Komnenou, Anastasia; Mangioris, Georgios; Kalpatsanidis, Antonis; Manthos, A.; Georgiadis, Nikolaos; Karampatakis, Vasileios

doi:10.5301/ejo.5000253

Cited by 5 publications

(8 citation statements)

References 19 publications

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“…One of the challenges with the application of current bioadhesives in ophthalmology is the consistency of the bioadhesive at the time of application. [ 6 ] Specifically, the bioadhesive besides having strong adhesion after polymerization, requires robust cohesion before cross‐linking. If the bioadhesive has a low cohesion (very liquid) it will easily spread over the field to undesired areas before cross‐linking, while if it is too viscous (very high cohesion), it will not adequately spread to provide coverage of the targeted area.…”

Section: Resultsmentioning

confidence: 99%

“…One of the challenges with the application of current bioadhesives in ophthalmology is the consistency of the bioadhesive at the time of application. [6] Specifically, the bioadhesive besides having strong adhesion after polymerization, requires The fabrication process of light-curable COMatrix (LC-COMatrix) hydrogel. Porcine corneas were decellularized using freeze-thaw method and partially digested with pepsin/HCl cocktail to fabricate thermoresponsive COMatrix hydrogel.…”

Section: Viscosity Characterization and Photogelation Kinetics Of Lig...mentioning

confidence: 99%

“…Currently, none of the available tissue sealants in the market such as fibrin glue (e.g., VISTASEAL, TISSEEL), cyanoacrylate based bioglues (e.g., Histoacryl, DERMABOND), and polyethylene glycol (PEG)‐based bioglues (ReSure, OcuSeal) are suitable as a pro‐regenerative corneal stromal replacement, and could be applied only for temporary sealing of ocular penetrations. [ 4 ] Fibrin gels are limited by the lack of necessary biomechanical stability and time‐consuming preparations, [ 5 ] cyanoacrylate is opaque and provides no opportunity for biointegration, [ 6 ] and the PEG‐based products lack the stability and strength for application in larger corneal defects. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

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A Light‐Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture‐Free Corneal Repair

Yazdanpanah

Shen

Nguyen

et al. 2022

Adv Funct Materials

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Corneal injuries are a major cause of blindness worldwide. To restore corneal integrity and clarity, there is a need for regenerative biointegrating materials for in situ repair and replacement of corneal tissue. Here, light-curable cornea matrix (LC-COMatrix), a tunable material derived from decellularized porcine cornea extracellular matrix containing un-denatured collagen and sulfated glycosaminoglycans is introduced. It is a functionalized hydrogel with proper swelling behavior, biodegradation, and viscosity that can be cross-linked in situ with visible light, providing significantly enhanced biomechanical strength, stability, and adhesiveness. The cross-linked LC-COMatrix strongly adheres to human corneas ex vivo and effectively closes full-thickness corneal perforations with tissue loss. Likewise, in vivo, LC-COMatrix seals large corneal perforations, replaces partial-corneal stromal defects and biointegrates into the tissue in rabbit models. LC-COMatrix is a natural ready-to-apply biointegrating adhesive that is representative of native corneal matrix with potential applications in corneal and ocular surgeries.

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Section: Resultsmentioning

confidence: 99%

“…One of the challenges with the application of current bioadhesives in ophthalmology is the consistency of the bioadhesive at the time of application. [6] Specifically, the bioadhesive besides having strong adhesion after polymerization, requires The fabrication process of light-curable COMatrix (LC-COMatrix) hydrogel. Porcine corneas were decellularized using freeze-thaw method and partially digested with pepsin/HCl cocktail to fabricate thermoresponsive COMatrix hydrogel.…”

Section: Viscosity Characterization and Photogelation Kinetics Of Lig...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Light‐Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture‐Free Corneal Repair

Yazdanpanah

Shen

Nguyen

et al. 2022

Adv Funct Materials

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show abstract

“…40 Given this speed of polymerization, it can be difficult to remove excess cyanoacrylate glue, which can result in crusting that is irritating to the patient. 41 In addition, the low viscosity of the glue before polymerization makes inadvertent spread onto the ocular surface difficult to avoid. Cyanoacrylate glue is also not biodegradable and releases toxic bi-products, like formaldehyde, that can cause inflammation, neovascularization, and cytotoxicity, which is not ideal for wound healing.…”

Section: Alternative Methods Of Globe Closure: Contact Lenses and Ocu...mentioning

confidence: 99%

Ophthalmic Trauma-Related Instruments—Critical Tools for Winning the Case

Sokol,

Rossin

2024

International Ophthalmology Clinics

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“…Compared to cyanoacrylate, fibrin glue may be less toxic but not as readily available [ 120 ]. Furthermore, a study found fibrin glue to be easier to use than cyanoacrylate glue due to less crust formation on the corneal surface, which can be irritating to the patient [ 124 ]. However, fibrin glue requires a significantly longer time for adhesive plug formation compared to cyanoacrylate adhesive [ 125 ].…”

Section: Mechanical Barrier Therapiesmentioning

confidence: 99%

Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets

Dang

Riaz

Karamichos

2022

Drugs

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Corneal injuries can occur secondary to traumatic, chemical, inflammatory, metabolic, autoimmune, and iatrogenic causes. Ocular infection may frequently occur concurrent to corneal injury; however, antimicrobial agents are excluded from this present review. While practitioners may primarily rely on clinical examination techniques to assess these injuries, several pharmacological agents, such as fluorescein, lissamine green, and rose bengal, can be used to formulate a diagnosis and develop effective treatment strategies. Practitioners may choose from several analgesic medications to help with patient comfort without risking further injury or delaying ocular healing. Atropine, cyclopentolate, scopolamine, and homatropine are among the most frequently used medications for this purpose. Additional topical analgesic agents may be used judiciously to augment patient comfort to facilitate diagnosis. Steroidal anti-inflammatory agents are frequently used as part of the therapeutic regimen. A variety of commonly used agents, including prednisolone acetate, loteprednol, difluprednate, dexamethasone, fluorometholone, and methylprednisolone are discussed. While these medications are effective for controlling ocular inflammation, side effects, such as elevated intraocular pressure and cataract formation, must be monitored by clinicians. Non-steroidal medications, such as ketorolac, bromfenac, nepafenac, and diclofenac, are additionally used for their efficacy in controlling ocular inflammation without incurring side effects seen with steroids. However, these agents have their own respective side effects, warranting close monitoring by clinicians. Additionally, ophthalmologists routinely employ several agents in an off-label manner for supplementary control of inflammation and treatment of corneal injuries. Patients with corneal injuries not infrequently have significant ocular surface disease, either as a concurrent pathology or as an exacerbation of previously existing disease. Several agents used in the management of ocular surface disease have also been found to be useful as part of the therapeutic armamentarium for treatment of corneal injuries. For example, several antibiotics, such as doxycycline and macrolides, have been used for their anti-inflammatory effects on specific cytokines that are upregulated during acute injuries. There has been a recent wave of interest in amniotic membrane therapies (AMTs), including topical, cryopreserved and dehydrated variants. AMT is particularly effective in ocular injuries with violation of corneal surface integrity due to its ability to promote reepithelialization of the corneal epithelium. Blood-based therapies, including autologous serum tears, plasma-enriched growth factor eyedrops and autologous blood drops, have additionally been explored in small case series for effectiveness in challenging and recalcitrant cases. Protection of the ocular surface is also a vital component in the treatment of corneal injuries. Temporary protective methods, such as bandage contact lenses and me...

show abstract

Experimental Application of Tissue Adhesives in Corneal Traumas

Abstract: Fibrin glue for the reconstruction of corneal wounds was easier to use than cyanoacrylate glue and caused less glue crust formation on the corneal surface. The speed of polymerization is an important factor. Excessive glue on the cornea was irritating.

Cited by 5 publications

References 19 publications

A Light‐Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture‐Free Corneal Repair

A Light‐Curable and Tunable Extracellular Matrix Hydrogel for In Situ Suture‐Free Corneal Repair

Ophthalmic Trauma-Related Instruments—Critical Tools for Winning the Case

Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets

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