Experimental assessment of small intestinal submucosa as a small bowel graft in a rat model

Wang, Zhong Qiu; Watanabe, Yasuhiro; Toki, Akira

doi:10.1016/s0022-3468(03)00567-0

Cited by 60 publications

(58 citation statements)

References 28 publications

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“…Chen and Badylak 19 produced three regenerated layers of intestine using a patch of small intestine submucosa in a canine model, but they failed to produce regeneration with a tube of small intestine submucosa. In a rat model, Wang and colleagues 20 reported successful regeneration of tubular intestine using sheets of small intestine submucosa wrapped on a silicone stent, but the quantity and organization of muscle layer differed from that of the native small bowel. Circular muscle appeared predominant, but longitudinal muscle was absent.…”

Section: Introductionmentioning

confidence: 99%

Intestinal regeneration by a novel surgical procedure

Jwo

Chiu

et al. 2008

British Journal of Surgery

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Section: Introductionmentioning

confidence: 99%

Intestinal regeneration by a novel surgical procedure

Jwo

Chiu

et al. 2008

British Journal of Surgery

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“…Various attempts to use synthetic materials for the patch did not give good results [2,11,14]. The fi rst report of creating novel intestinal surface using an animal model came in 1973 when Binnington and colleagues performed an incision on the antimesenteric border of the jejunum and patched this opening using the serosa of the adjacent descending colon.…”

Section: Discussionmentioning

confidence: 99%

“…Many experiments tried to promote different methods to multiply the enterocyte mass [11][12][13]. All experiments have been set up so that the short bowel syndrome was induced in experimental animals in order for the multiplication of the enterocyte mass to begin afterwards, which made both the operative procedure and the postoperative care complicated [6].…”

Section: Introductionmentioning

confidence: 99%

Multiplication of the Enterocyte Mass by Serosal Patch Technique / Umnožavanje Enterocitne Mase Tehnikom Seroznog Patch-A

et al. 2015

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Damage to the small intestine and impairment of the intestinal epithelium occur in various diseases, resulting in a need for new epithelium. Therefore, bioengineering of the small intestine is becoming an attractive fi eld of research where all contributions are highly appreciated.The purpose of this study was to determine the possibility of the multiplication of the enterocyte mass using the technique of serosal patch with the application of hematopoietic stem cells, as well as the assessment of the quality of newly formed mucosa.Sixty Mill Hill hooded rats were divided in 4 groups, 15 animals each. In the control group animals, the patch was not created. In the other three groups, the animals were operated on and in each group 8 parietal and 7 visceral patches have been created. One of the groups with operated animals (Group NS) was not postoperatively treated. The second group of operated animals (Group G) was stimulated with granulocyte colony-stimulating factor (G-CSF). The third group of operated animals (Group GM) was stimulated with recombined humane granulocyte-macrophage colony-stimulating factor (rHuGM-CSF).In the group of animals that were not stimulated, epithelium proliferated slowly. In the group of animals stimulated with G-CSF stimulants, the epithelium initially proliferated rapidly, but appeared atrophic after eight weeks. Stimulation by rHuGM-CSF led to faster epithelization, and epithelium showed signs of advancing proliferation after eight weeks.We confi rmed the possibility of enterocyte mass multiplication by using the serosal patch technique, as well as that stimulation with rHuGM-CSF is more effective than stimulation with G-CSF.

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“…Wang et al [55] recently interposed a 2-cm length of tubular small intestinal submucosa graft from donor rats with a bilateral anastomosis in the middle of an isolated ileal loop, and documented a rapid regeneration of mucosa and smooth muscle in the graft. The authors concluded that a small intestinal submucosa graft might be a viable material for the creation of neointestine.…”

Section: Sbs and Transplantationmentioning

confidence: 99%

Advances in short bowel syndrome: an updated review

et al. 2005

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Short bowel syndrome (SBS) continues to be an important clinical problem due to its high mortality and morbidity as well as its devastating socioeconomic effects. The past 3 years have witnessed many advances in the investigation of this condition, with the aim of elucidating the cellular and molecular mechanisms of intestinal adaptation. Such information may provide opportunities to exploit various factors that act as growth agents for the remaining bowel mucosa and may suggest new therapeutic strategies to maintain gut integrity, eliminate dependence on total parenteral nutrition, and avoid the need for intestinal transplantation. This review summarizes current research on SBS over the last few years.

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Experimental assessment of small intestinal submucosa as a small bowel graft in a rat model

Cited by 60 publications

References 28 publications

Intestinal regeneration by a novel surgical procedure

Intestinal regeneration by a novel surgical procedure

Multiplication of the Enterocyte Mass by Serosal Patch Technique / Umnožavanje Enterocitne Mase Tehnikom Seroznog Patch-A

Advances in short bowel syndrome: an updated review

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