Experimental assessment of spectrum analysis of ultrasonic echoes as a method for estimating scatterer properties

Hosokawa, Tetsuya; Sigel, Bernard; Machi, Junji; Kitamura, Hiroshi; Kolecki, Robert V.; Justin, Jeffery; Feleppa, Ernest J.; Tuszynski, George P.; Kakegawa, Teruo

doi:10.1016/0301-5629(94)90101-5

Cited by 16 publications

(5 citation statements)

References 19 publications

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“…A number of experimental studies utilizing these models have been performed (Insana 1996;Hosokawa et al 1994;Garra et al 1994), including characterization of renal disease (Insana 1996;Garra et al 1994), liver disease (Stetson and Sommer 1997), breast tumors (Anderson et al 2001;Donohue et al 2001), skin (Fournier et al 2001) and atherosclerotic plaque (Moore et al 1998;Watson et al 2000;Nair et al 2001), among others. This general methodology has been applied by our research group for characterization of ocular tumors (Coleman et al 2004;Liu et al 2004;Silverman et al 2003) and prostate cancer (Feleppa et al 2002;Feleppa et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Improved visualization of high-intensity focused ultrasound lesions

Silverman

Muratore

Ketterling

et al. 2006

Ultrasound in Medicine & Biology

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Spectral parameter imaging in both the fundamental and harmonic of backscattered radiofrequency (RF) data was used for immediate visualization of high-intensity focused ultrasound (HIFU) lesion sites. A focused 5-MHz HIFU transducer with a coaxial 9-MHz focused single-element diagnostic transducer was used to create and scan lesions in chicken breast and freshly excised rabbit liver. Bmode images derived from the backscattered RF signal envelope were compared with midband fit (MBF) spectral parameter images in the fundamental (9-MHz) and harmonic (18-MHz) bands of the diagnostic probe. Images of HIFU-induced lesions derived from the MBF to the calibrated spectrum showed improved contrast (~ 3 dB) of tumor margins versus surround compared to images produced from the conventional signal envelope. MBF parameter images produced from the harmonic band showed higher contrast in attenuated structures (core, shadow) compared to either the conventional envelope (3.3 dB core; 11.6 dB shadow) or MBF images of the fundamental band (4.4 dB core; 7.4 dB shadow). The gradient between the lesion and surround was 3.4 dB/mm, 6.9 dB/mm and 17.2 dB/mm for B-mode, MBF-fundamental mode and MBF-harmonic mode respectively. Images of threshold and 'popcorn' lesions produced in freshly excised rabbit liver were most easily visualized and boundaries best defined using MBF-harmonic mode.

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Section: Introductionmentioning

confidence: 99%

Improved visualization of high-intensity focused ultrasound lesions

Silverman

Muratore

Ketterling

et al. 2006

Ultrasound in Medicine & Biology

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“…6 Below this ka value, it is difficult to differentiate the scatterers from point scatterers. 33 Furthermore, if the ka value is too large, the measured form factor has a small magnitude leading to less accurate estimates. Figure 10 shows the percent error in estimates made of the average scatterer diameter compared with the actual scatterer diameter using the gate-edge correction, the rectangular window, and the Hanning window.…”

Section: Simulation and Experimental Resultsmentioning

confidence: 99%

Improved scatterer property estimates from ultrasound backscatter for small gate lengths using a gate-edge correction factor

Oelze

O’Brien

2004

The Journal of the Acoustical Society of America

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Backscattered rf signals used to construct conventional ultrasound B-mode images contain frequency-dependent information that can be examined through the backscattered power spectrum. The backscattered power spectrum is found by taking the magnitude squared of the Fourier transform of a gated time segment corresponding to a region in the scattering volume. When a time segment is gated, the edges of the gated regions change the frequency content of the backscattered power spectrum due to truncating of the waveform. Tapered windows, like the Hanning window, and longer gate lengths reduce the relative contribution of the gate-edge effects. A new gate-edge correction factor was developed that partially accounted for the edge effects. The gate-edge correction factor gave more accurate estimates of scatterer properties at small gate lengths compared to conventional windowing functions. The gate-edge correction factor gave estimates of scatterer properties within 5% of actual values at very small gate lengths (less than 5 spatial pulse lengths) in both simulations and from measurements on glass-bead phantoms. While the gate-edge correction factor gave higher accuracy of estimates at smaller gate lengths, the precision of estimates was not improved at small gate lengths over conventional windowing functions.

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“…Hosokowa et al attempted to validate the theory underlying spectrum analysis using widely spaced, spherical cell clusters cultured in a collagen-based medium to represent ideal scatterers and obtained results that matched theoretical predictions over a limited range of scatterer (i.e., cell cluster) sizes [42]. More recently, investigators, such as Kolios, Czarnota, Oelze, Mamou, and Bigelow, have made valuable contributions to spectral methods by advancing insights into underlying mechanisms and by extending and refining the scattering theory associated with spectral behaviors [43][44][45][46][47][48][49][50][51][52].…”

Section: Spectrum Analysismentioning

confidence: 86%

Experimental assessment of spectrum analysis of ultrasonic echoes as a method for estimating scatterer properties

Cited by 16 publications

References 19 publications

Improved visualization of high-intensity focused ultrasound lesions

Improved visualization of high-intensity focused ultrasound lesions

Improved scatterer property estimates from ultrasound backscatter for small gate lengths using a gate-edge correction factor

Imaging the Prostate with Quantitative Ultrasound: Implications for Guiding Biopsies, Targeting Focal Treatment, and Monitoring Therapy

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