Experimental atrophy/hypertrophy complex (AHC) of the liver: portal vein, but not bile duct obstruction, is the main driving force for the development of AHC in the rat

Schweizer, W; Duda, P; Tanner, Steven F.; Balsiger, D; Höflin, F.; Blumgart, L H; Zimmermann, Arthur

doi:10.1016/0168-8278(95)80313-0

Cited by 43 publications

(35 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The possible way of high-volumetric resection with sufficient retention of hepatic function is the iatrogenic partial hypertrophy of preserved lobes. The role of vein ligation was proved by previous researches [16]. In our case ligation of right branch of portal vein was performed.…”

Section: Discussionmentioning

confidence: 99%

Case report: High-volumetric atypical hemihepatectomy in patient with colorectal cancer with extensive metastatic disease

Sjomina¹,

Pavlova²,

Gashenko³

et al. 2017

Liver Pancreat Sci

View full text Add to dashboard Cite

Hepatic metastasectomy in colorectal cancer is becoming a routine procedure, however the presence of extrahepatic metastatic disease worsens the life expectancy. A high-volumetric hepatic resection in case of multiple liver metastases might be performed after iatrogenic liver hypertrophy aimed to enlarge functional liver volume. Ligation or embolization of portal vein can be done. The outcome of the procedure is significantly improved using newest chemotherapy regimens and biological medications. We report a case with successful combined therapy of a 49-year-old male with colorectal cancer and bilateral extended metastatic process in liver and lungs.

show abstract

Section: Discussionmentioning

confidence: 99%

Case report: High-volumetric atypical hemihepatectomy in patient with colorectal cancer with extensive metastatic disease

Sjomina¹,

Pavlova²,

Gashenko³

et al. 2017

Liver Pancreat Sci

View full text Add to dashboard Cite

show abstract

“…(15,(27)(28)(29)(30)(31)(32). Atrophy in ligated lobe and hypertrophy in opposite lobe have been observed in human and animals and this was called Atrophy/Hypertrophy complex (AHC) (14). At least two hypothesis have been suggested about the controlling of cell proliferation triggering in liver resection.…”

Section: Discussionmentioning

confidence: 99%

“…Second; Cell to cell contact inhibition gets lost and proliferation occurs due to activation of regeneration stimulators in suboptimal remnant liver tissue (15,22). Schweizer et.al (14) had constituted AHC model in rats. They had shown that AHC occurred with PVL and/or PVL with ligation of one of ductus hepaticus together, but not with ligation of a ductus hepaticus alone.…”

Section: Discussionmentioning

confidence: 99%

“…Liver has extremely good regeneration ability and this ability is controlled with hepatotrophic factors and inhibitor agents (14,(20)(21)(22)(23)(24)(25)(26). It has been known that vena portae carries hepatotrophic factors (Insulin, glucagon etc.)…”

Section: Discussionmentioning

confidence: 99%

“…It is known that portal blood carries the materials having trophic effects that cause hypertrophy and hyperplasia (10,11). In animal and human experiments, after the ligation of portal vein, atrophy has been observed in the same side of ligation and hypertrophy in the opposite side (Atrophy/ Hypertrophy complex (AHC) (12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Outcome of Major Hepatectomies Following Different Durations of Portal Vein Ligation in Rats

et al. 2005

View full text Add to dashboard Cite

Portal Vein Ligation as an Efficient Method of Increasing the Future Liver Remnant Volume in the Surgical Treatment of Colorectal Metastases

et al. 2008

View full text Add to dashboard Cite

To compare the volumetric increase of segments 2 and 3, segment 4, and the caudate lobe after portal vein ligation (PVL) and portal vein embolization (PVE). The small size of the remnant liver and chemotherapyinduced liver injury increase the risk of postoperative hepatic insufficiency after major hepatic resection for colorectal liver metastases. Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver. Design, Setting, and Patients: We retrospectively reviewed 48 patients with colorectal liver metastases who underwent PVL (n=17) or PVE (n=31) at the Istituto per la Ricerca e la Cura del Cancro or the Institut

show abstract

Experimental atrophy/hypertrophy complex (AHC) of the liver: portal vein, but not bile duct obstruction, is the main driving force for the development of AHC in the rat

Cited by 43 publications

References 23 publications

Case report: High-volumetric atypical hemihepatectomy in patient with colorectal cancer with extensive metastatic disease

Case report: High-volumetric atypical hemihepatectomy in patient with colorectal cancer with extensive metastatic disease

The Outcome of Major Hepatectomies Following Different Durations of Portal Vein Ligation in Rats

Portal Vein Ligation as an Efficient Method of Increasing the Future Liver Remnant Volume in the Surgical Treatment of Colorectal Metastases

Contact Info

Product

Resources

About