Experimental Attempts to Transmit Phlebotomus (Sandfly, Pappataci) and Dengue Fevers to Chimpanzees.

Paul, John R.; Melnick, J. L.; Sabin, A. B.

doi:10.3181/00379727-68-16431

Cited by 11 publications

(8 citation statements)

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“…The only large animal species besides humans that are known to be naturally infected and can be experimentally infected by the parenteral route are monkeys [110–115] and apes [97]. The antibody response and viremia levels in monkeys are similar to that seen in humans [111], and therefore they have been viewed as an acceptable animal model to study virological and immunological aspects in experimental dengue virus infections [116–119].…”

Section: In Vivo Animal Studiesmentioning

confidence: 99%

Cells in Dengue Virus Infection In Vivo

Noisakran

Onlamoon

Songprakhon

et al. 2010

Advances in Virology

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Dengue has been recognized as one of the most important vector-borne emerging infectious diseases globally. Though dengue normally causes a self-limiting infection, some patients may develop a life-threatening illness, dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The reason why DHF/DSS occurs in certain individuals is unclear. Studies in the endemic regions suggest that the preexisting antibodies are a risk factor for DHF/DSS. Viremia and thrombocytopenia are the key clinical features of dengue virus infection in patients. The amounts of virus circulating in patients are highly correlated with severe dengue disease, DHF/DSS. Also, the disturbance, mainly a transient depression, of hematological cells is a critical clinical finding in acute dengue patients. However, the cells responsible for the dengue viremia are unresolved in spite of the intensive efforts been made. Dengue virus appears to replicate and proliferate in many adapted cell lines, but these in vitro properties are extremely difficult to be reproduced in primary cells or in vivo. This paper summarizes reports on the permissive cells in vitro and in vivo and suggests a hematological cell lineage for dengue virus infection in vivo, with the hope that a new focus will shed light on further understanding of the complexities of dengue disease.

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Section: In Vivo Animal Studiesmentioning

confidence: 99%

Cells in Dengue Virus Infection In Vivo

Noisakran

Onlamoon

Songprakhon

et al. 2010

Advances in Virology

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“…Animal models of DENV could facilitate an understanding of the progress of DENV infection [2]. Non-human primates, including rhesus monkeys, cynomolgus monkeys, and owl monkeys, have been used in studies on pathophysiology of DENV infection and vaccine evaluation [3][4][5][6][7][8][9][10][11][12]. Because not all nonhuman primate models develop overt levels of viremia and clinical signs, a suitable animal model that consistently develops high levels of viremia and clinical signs would provide an effective tool in vaccine evaluation and elucidation of the pathogenesis of DENV infection [13].…”

Section: Introductionmentioning

confidence: 99%

Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus

Omatsu

Moi

Takasaki

et al. 2012

J of Medical Primatology

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Background Marmosets are susceptible to dengue virus (DENV) infection. However, blood parameter data and clinical signs of DENV-infected marmosets are limited. Methods Blood hematological and serum biochemical values were obtained from twelve DENV-inoculated and four mock-infected marmosets. Additionally, body temperature and activity level were determined. Results Five DENV-inoculated marmosets demonstrated thrombocytopenia, nine demonstrated leucopenia, and five demonstrated an increase in the levels of AST, ALT, LDH, and BUN. Additionally, seven DENV-inoculated marmosets demonstrated clinical signs including fever and decreases in activity. None of the four mock-inoculated marmosets demonstrated changes in either hematological or biochemical parameters. Conclusions Marmosets inoculated with DENV exhibited clinical signs and changes in hematological and biochemical parameters. The results suggest that blood parameter data and clinical signs could potentially be useful markers for understanding the progress of DENV infection in studies using marmosets.

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“…The classical/conventional viral particles typically observed in fibroblast, lymphoblast or mosquito cell cultures, have a slightly heavier density [28,29]. The earliest documentation on the diversity of the infectious dengue virus was addressed by Paul et al [30]. Pooled samples of infected human serum obtained from patients acutely ill with dengue were preserved in a frozen state and then thawed and separated into two fractions, top and bottom, by differential centrifugation.…”

Section: Dynamic Viral Particles In Infected Hostsmentioning

confidence: 99%

“…Systemic research suggests that the nonhuman primate immune system and its responses, including profiles to dengue virus infection, are very similar to that of human beings. Chimpanzees and monkeys have been found to be highly susceptible for dengue virus infection, though the cardinal features present in human disease are hardly seen in these infected animals [30,46]. Therefore, humans, monkeys and chimpanzees are viewed to be the natural hosts for dengue virus.…”

Section: Nonhuman Primatesmentioning

confidence: 99%

Dengue Vaccines: Challenge and Confrontation

Perng¹,

Lei²,

Lin³

et al. 2011

WJV

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Dengue has been recognized as one of the most important vector-borne human diseases. The disease is induced by dengue virus infection resulting from the bite of an infected Aedes spp. mosquito after imbibing the tainted blood from animals or patients. Dynamic clinical spectrums ranging from asymptomatic, undifferentiated fever, typical dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) have been well documented. Initially, the disease was mainly restricted in tropical and subtropical zones. However, with factors such as ineffective vector control, frequency of human migration, unplanned urbanization, and changing climate temperature, the disease has been spotted at almost every territory of the earth. Dengue has been associated with human disease for more than two centuries. Although classic DF is viewed as a self-limited illness, subjects normally resolve within two weeks and recover without any noticeable complications or sequelae, some of these infected individuals may progress to life-threatening DHF/DSS, characterized with plasma leakage due to an increase in capillary permeability. The significantly increased public health threat and the burden of morbidity and mortality of dengue globally has caught the attention of public officials and prompted an action to find a way to contain and prevent the disease. The lack of specific dengue therapeutics has led to an emphasis on vaccine development, one of the best and effective strategies to reduce and prevent the illness. Making a dengue vaccine has been attempted more than six decades; although some of these products are in clinical trials, vaccine development for the prevention of dengue disease is still at its infancy. So far no dengue vaccine is available for the public. Dengue vaccine development may be hindered by the complexity of the clinical presentations, which implicates that multiple pathogenic mechanisms are involved in dengue disease. Some of these elements will be discussed in the current review. Opening up discussion on these pros and cons and engaging in more research to understand these features would not only improve the understanding of the pathogenesis of the dengue virus infection but also pave a new tactic to develop a safer and effective dengue vaccine

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Experimental Attempts to Transmit Phlebotomus (Sandfly, Pappataci) and Dengue Fevers to Chimpanzees.

Cited by 11 publications

References 0 publications

Cells in Dengue Virus Infection In Vivo

Cells in Dengue Virus Infection In Vivo

Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus

Dengue Vaccines: Challenge and Confrontation

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