The flexural behavior of partially welded flush end-plate connections incorporating built-up hybrid beams and columns is analytically and numerically investigated. An experimentally obeying three-dimensional finite element model is first constructed. To circumvent the laborious effort of three-dimensional simulation and experimental work, a new experimentally and numerically complying equation approach is introduced for the construction of a continuous moment-rotation (M-u) description. For the proposed equation, two essential terms are required: the rotational stiffness, S j,ini , obtained by employing the component method and the maximum moment, M max , produced using the proposed linearly distributed multi-parameter fitting technique. To demonstrate the applicability of the proposed equation, a variation in the geometric configuration of connections within the practical range is considered. Excellent agreement is noted when comparing all M-u relationships produced by the proposed equation to those by the finite element method and experiments. In addition, the stress distribution and main deformation modes are numerically obtained, where the ranking of stress criticality is offered for all structural parts. The depth, width, flange, and web thicknesses, as well as the yield stress of the beam, have a major influence on M max , as predicted by the proposed equation. Also, bolts have been identified as the most critically stressed component.