Experimental bilharzial squamous metaplasia of the urinary bladder in hamsters

B, el-Morsi; Sherif, Mohamed H.; El-Raziki, E.S.

doi:10.1016/0014-2964(75)90117-6

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Rates of hamster bladder involvement after exposure to S. haematobium cercaria are low and inconsistent, ranging from 0 to approximately 60%. Even when bladder oviposition occurs, egg burdens tend to be much lighter than that found in other organs, and less than two-thirds of hamsters with bladder eggs feature urothelial hyperplasia or squamous metaplasia [45]. Thus, hamsters develop clinical pathology which can differ dramatically from human disease, restricting their biological relevance.…”

Section: Discussionmentioning

confidence: 99%

A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

et al. 2012

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Schistosoma haematobium is the etiologic agent for urogenital schistosomiasis, a major source of morbidity and mortality for more than 112 million people worldwide. Infection with S. haematobium results in a variety of immunopathologic sequelae caused by parasite oviposition within the urinary tract, which drives inflammation, hematuria, fibrosis, bladder dysfunction, and increased susceptibility to urothelial carcinoma. While humans readily develop urogenital schistosomiasis, the lack of an experimentally-tractable model has greatly impaired our understanding of the mechanisms that underlie this important disease. We have developed an improved mouse model of S. haematobium urinary tract infection that recapitulates several aspects of human urogenital schistosomiasis. Following microinjection of purified S. haematobium eggs into the bladder wall, mice consistently develop macrophage-rich granulomata that persist for at least 3 months and pass eggs in their urine. Importantly, egg-injected mice also develop urinary tract fibrosis, bladder dysfunction, and various urothelial changes morphologically reminiscent of human urogenital schistosomiasis. As expected, S. haematobium egg-induced immune responses in the immediate microenvironment, draining lymph nodes, and systemic circulation are associated with a Type 2-dominant inflammatory response, characterized by high levels of interleukin-4, eosinophils, and IgE. Taken together, our novel mouse model may help facilitate a better understanding of the unique pathophysiological mechanisms of epithelial dysfunction, tissue fibrosis, and oncogenesis associated with urogenital schistosomiasis.

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Section: Discussionmentioning

confidence: 99%

A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

et al. 2012

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“…Although some researchers have advanced arguments favoring such a direct or indirect relationship, others have rejected it as coincidental or fortuitous 2,7,8,[11][12][13][14][15][16][17][18][19][20][21][22] (Tables 1 and 2). Hicks, in a very attractive experimental study, was successful in inducing the development of bladder cancer in baboons injected with Schistosoma haematobium and in which the process of carcinogenesis had been initiated with N-butyl N-(4-hydroxybutyl) nitrosamine (BRN).…”

Section: Causal Relationship Between Urinary Bilharziasis and Bladdermentioning

confidence: 99%