Experimental bilirubin encephalopathy. The mode of entry of bilirubin-14C into the central nervous system.

Bilirubin and the Auditory System

“…There are differences in ABR wave latencies and amplitudes in jaundiced Gunn rats during development and in adulthood. 14,15 When infant jaundiced Gunn rats are given a sulfonamide to displace bilirubin from blood (albumin) into brain tissue, 16 there were acute increases in interwave intervals and decreases in amplitudes of ABR waves II and III, which correspond to waves III and V of the human, respectively. 17 These changes occur within an hour or two after toxicity, sometimes within minutes, and are reversible.…”

Mode of Inhibitory Action of Bilirubin on Protein Kinase C

“…Acidosis or hypoalbuminemia increases unbound bilirubin levels allowing the accumulation of bilirubin in central nervous tissues (17). Therefore, experiments using premature or very early neonatal animals with hyperbilirubinemia are necessary in order to clarify precisely the role of protein kinases in kernicterus.…”

Antibiotics in pregnancy: Toxicity and teratogenicity

“…Sulfonamides administered to newborns or to mothers in the third trimester of pregnancy can displace the unconjugated bilirubin from the plasma albumin. The liberated bilirubin may then enter the tissues and the brain and produce the so-called kernicterus (27,28). The last compound listed in Table 2, trimethoprim, distributes well across the placenta.…”