Experimental Bowel Ischemia

Ranniger, Klaus; Scheiner, David L.

doi:10.1001/archsurg.1967.01330170076010

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…When microspheres were injected in experiments by Boley et al (1965) and Ranniger and Scheiner (1967) the microspheres lodged at the bifurcation of blood vessels. The latter authors showed that the important factor in producing ischaemic disease is the quantity of microspheres injected.…”

Section: Microcirculationmentioning

confidence: 99%

Ischaemic colitis in the experimental animal. II. Role of hypovolaemia in the production of the disease.

Matthews¹,

Parks²

1976

Gut

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SUMMARY Hypovolaemia alone did not lead to ischaemic colitis but when venesection was induced immediately after the acute ligation of the common colic artery large bowel ischaemia ensued. Similarly, hypovolaemia induced one month after two major blood vessels had been occluded led to ischaemic colitis. These findings suggest that states of low blood flow in the presence of previous arterial constriction or blockage may lead to enough reduction in mesenteric perfusion for intestinal ischaemia to develop. Using an electromagnetic flowmeter placed in the cranial mesenteric artery of the dog, it was shown that hypovolaemia may lead to 50-75% reduction in mesenteric blood flow without producing any significant change in the systemic blood pressure.

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Section: Microcirculationmentioning

confidence: 99%

Ischaemic colitis in the experimental animal. II. Role of hypovolaemia in the production of the disease.

Matthews¹,

Parks²

1976

Gut

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“…Using the Seldinger technique, Ranniger and Scheiner (1967) injected lead pellets into the cranial (superior) mesenteric artery of dogs and found that the degree of vascular embarrassment produced Received for publication 19 May 1976 depended on the number of pellets introduced. If several adjacent intramural branches were occluded the acute ischaemia led to gangrene and perforation of the bowel within 15 hours, in spite of collateral circulation.…”

mentioning

confidence: 99%

Ischaemic colitis in the experimental animal. I. Comparison of the effects of acute and subacute vascular occlusion.

Matthews¹,

Parks²

1976

Gut

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SUMMARY Acute ligation of the common colic and caudal mesenteric artery in the dog led to ischaemic colitis, whereas the acute ligation of the common colic artery and gradual occlusion of the caudal mesenteric artery by an ameroid plastic device did not lead to ischaemic disease. These findings suggest that the collateral blood vessels do not open up rapidly enough to prevent ischaemic change when the two major arteries are acutely ligated.For a number of years, attempts have been made to render the large bowel ischaemic experimentally. Boley et al. (1963) carried out experiments in which they ligated the colonic arteries in dogs and they also undertook other studies in which either venous or combined arterial and venous interruption was effected. They produced appearances some of which resembled ischaemic colitis in man.Marston et al. (1969) adopted similar techniques which involved acute ligation of the common colic, the caudal mesenteric, and the marginal arteries in the dog. The extent of devascularisation ranged from the acute ligation of the caudal mesenteric artery alone, to subtotal devascularisation where all three arteries were ligated at once. Definite structural lesions were produced which varied in timing and severity according to the degree of the devascularisation procedure.Boley et a!. (1965) investigated the effects of blockage of the vasa recta with microsphere emboli. Ceramic and glass microspheres varying in diameter from 35 to 100 microns were injected into the caudal mesenteric artery in dogs. This resulted in a spectrum ofpathological change ranging from minimalmucosal oedema to rapid total intestinal necrosis, the severity depending on the size and quantity of the spheres injected. The larger the quantity and the smaller the spheres the greater was the damage produced.Using the Seldinger technique, Ranniger and Scheiner (1967) injected lead pellets into the cranial (superior) mesenteric artery of dogs and found that the degree of vascular embarrassment produced

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